Evidence map›Paper›PMID 19786366›Full record

ArticleTrends in immunology2009

CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns.

Yang Liu, Guo-Yun Chen, Pan Zheng

Abstract read
In one paragraph

Article in Trends in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Neuromuscular complications associated with cancer immunotherapy.Journal of the National Cancer Center · 2025
    Review
  8. Article
  9. Extracellular vesicles in malignant and normal B lymphocyte growth and development.Extracellular vesicles and circulating nucleic acids · 2025
    Review
  10. Article
  11. Article
  12. Developmental trajectory of extracellular vesicle characteristics from the lungs of preterm infants.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  13. Review
  14. Surprising magic of CD24 beyond cancer.Frontiers in immunology · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yang LiuDivision of Immunotherapy, Section of General Surgery, Departments of Surgery and Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48105, USA. yangl@umich.edu
Guo-Yun Chen
Pan Zheng

Funding

Checkpoints of Host Response to Cellular InjuriesR01AI064350 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, YANG, ZHENG, PAN · 2006 to 2019
$5.6M
Tumor burden and T cell immunityR01CA058033 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, YANG · 1992 to 2013
$3.3M
mTOR, Inflammation and Senescence of Hematopoietic Stem CellsR01AG036690 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHENG, PAN · 2010 to 2014
$1.6M
Selective Modulation of Cancer Immunity and AutoimmunityR01CA112001 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, YANG · 2006 to 2010
$1.3M
CD24 Polymorphism and Acetaminophen ToxicityRC1GM091648 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHENG, PAN · 2009 to 2010
$998k
NCI NIH HHS CA58033NCI NIH HHS R01 CA058033NCI NIH HHS R01 CA112001NIAID NIH HHS AI64350NIAID NIH HHS R01 AI064350NIA NIH HHS R01 AG036690NIGMS NIH HHS RC1 GM091648
6 · The paper itself

Abstract

It is now well accepted that the innate immune system recognizes both damage (or danger)- and pathogen-associated molecular patterns (DAMP and PAMP, respectively) through pattern recognition receptors, such as Toll-like receptors (TLR) and/or Nod-like receptors (NLR). Less clear are whether and how the response to PAMP and DAMP are regulated differentially. The answers may reveal whether the primary goal of the immune system is to defend against infections or to alert the host of tissue injuries. We demonstrated recently that the host response to DAMP is controlled by a DAMP-CD24-Siglec axis. Here we propose a key role for the CD24-Siglec pathway in discriminating between DAMPs and PAMPs.

Indexed as

AnimalsCD24 AntigenHeat-Shock ProteinsHumansImmunity, InnateLectinsLymphocyte ActivationMiceNod1 Signaling Adaptor ProteinProtein BindingProtein Tyrosine Phosphatase, Non-Receptor Type 6Receptors, Pattern RecognitionSialic Acid Binding Immunoglobulin-like LectinsToll-Like Receptor 2Toll-Like Receptor 4CD24 AntigenHeat-Shock ProteinsLectinsNod1 Signaling Adaptor ProteinProtein Tyrosine Phosphatase, Non-Receptor Type 6Receptors, Pattern RecognitionSialic Acid Binding Immunoglobulin-like LectinsToll-Like Receptor 2Toll-Like Receptor 4

Identifiers

PMID19786366
PMCPMC2788100

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.