ArticleMolecular immunology2009
Role of alveolar epithelial early growth response-1 (Egr-1) in CD8+ T cell-mediated lung injury.
Article in Molecular immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children.The Journal of allergy and clinical immunology · 2021Article
- Nutritional approach for increasing public health during pandemic of COVID-19: A comprehensive review of antiviral nutrients and nutraceuticals.Health promotion perspectives · 2021Review
- EndogenousInternational journal of molecular sciences · 2019Article
- Egr-1 deficiency protects from renal inflammation and fibrosis.Journal of molecular medicine (Berlin, Germany) · 2016Article
- The cytokine storm of severe influenza and development of immunomodulatory therapy.Cellular & molecular immunology · 2016Review
- Inflammatory impact of IFN-γ in CD8+ T cell-mediated lung injury is mediated by both Stat1-dependent and -independent pathways.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- ADAM17-mediated processing of TNF-α expressed by antiviral effector CD8+ T cells is required for severe T-cell-mediated lung injury.PloS one · 2013Article
- Protective efficacy of orally administered, heat-killed Lactobacillus pentosus b240 against influenza A virus.Scientific reports · 2013Article
- Early growth response 3 (Egr3) is highly over-expressed in non-relapsing prostate cancer but not in relapsing prostate cancer.PloS one · 2013Article
- Immunopathogenesis of 2009 pandemic influenza.Enfermedades infecciosas y microbiologia clinica · 2012Review
- Host response to influenza virus: protection versus immunopathology.Current opinion in immunology · 2010Review
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Influenza infection of the distal airways results in severe lung injury, a considerable portion of which is immunopathologic and attributable to the host responses. We have used a mouse model to specifically investigate the role of antiviral CD8(+) T cells in this injury, and have found that the critical effector molecule is TNF-alpha expressed by the T cells upon antigen recognition. Interestingly, the immunopathology which ensues is characterized by significant accumulation of host inflammatory cells, recruited by chemokines expressed by the target alveolar epithelial cells. In this study we analyzed the mechanisms involved in the induction of epithelial chemokine expression triggered by antigen-specific CD8(+) T cell recognition, and demonstrate that the early growth response-1 (Egr-1) transcription factor is rapidly induced in epithelial cells, both in vitro and ex vivo, and that this is a critical regulator of a host of inflammatory chemokines. Genetic deficiency of Egr-1 significantly abrogates both the chemokine expression and the immunopathologic injury associated with T cell recognition, and it directly regulates transcriptional activity of a model CXC chemokine, MIP-2. We further demonstrate that Egr-1 induction is triggered by TNF-alpha-dependent ERK activation, and inhibition of this pathway ablates Egr-1 expression. These findings suggest that Egr-1 may represent an important target in mitigating the immunopathology of severe influenza infection.
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Registered trials
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