ArticleBone2010
Pathway-based genome-wide association analysis identified the importance of EphrinA-EphR pathway for femoral neck bone geometry.
Article in Bone, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Comparisons of reference curves for femoral neck geometric parameters between Changsha-Chinese women and women of three ethnic groups in the United States.Archives of osteoporosis · 2025Article
- Comparison of femoral neck geometric parameters between Chinese and Japanese females.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Role of mesenchymal stem cells in cell life and their signaling.World journal of stem cells · 2014Review
- Variation in the MC4R gene is associated with bone phenotypes in elderly Swedish women.PloS one · 2014Article
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- Article
- Bivariate genome-wide association analyses of femoral neck bone geometry and appendicular lean mass.PloS one · 2011Article
- Pathway-based association analyses identified TRAIL pathway for osteoporotic fractures.PloS one · 2011Article
- Analysing biological pathways in genome-wide association studies.Nature reviews. Genetics · 2010Review
- Molecular genetic studies of gene identification for osteoporosis: the 2009 update.Endocrine reviews · 2010Review
- The regulation-of-autophagy pathway may influence Chinese stature variation: evidence from elder adults.Journal of human genetics · 2010Article
- Genetics of osteoporosis: accelerating pace in gene identification and validation.Human genetics · 2010Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Femoral neck (FN) bone geometry is an important predictor of bone strength with high heritability. Previous studies have revealed certain candidate genes for FN bone geometry. However, the majority of the underlying genetic factors remain to be discovered. In this study, pathway-based genome-wide association analysis was performed to explore the joint effects of genes within biological pathways on FN bone geometry variations in a cohort of 1000 unrelated US whites. Nominal significant associations (nominal p value<0.05) were observed between 76 pathways and a key FN bone geometry variable-section modulus (Z), biomechanically indicative of bone strength subject to bending. Among them, EphrinA-EphR pathway was most significantly associated with FN Z even after multiple testing adjustments (p(FWER) value=0.035). The association of EphrinA-EphR pathway with FN Z was also observed in an independent sample from Framingham Osteoporosis Study. Overall, these results suggest the significant genetic contribution of EphrinA-EphR pathway to femoral neck bone geometry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.