ArticleFree radical biology & medicine2009
Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes.
Article in Free radical biology & medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
- Common and Uncommon Mouse Models of Growth Hormone Deficiency.Endocrine reviews · 2024Review
- Canagliflozin shares common mTOR and MAPK signaling mechanisms with other lifespan extension treatments.Life sciences · 2023Article
- Cap-independent translation of GPLD1 enhances markers of brain health in long-lived mutant and drug-treated mice.Aging cell · 2022Article
- Transient early life growth hormone exposure permanently alters brain, muscle, liver, macrophage, and adipocyte status in long-lived Ames dwarf mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Mouse models of growth hormone deficiency.Reviews in endocrine & metabolic disorders · 2021Review
- Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.Aging · 2020Article
- Ras signaling in aging and metabolic regulation.Nutrition and healthy aging · 2017Review
- A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Article
- Physiological underpinnings in life-history trade-offs in man's most popular selection experiment: the dog.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
- Article
- Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Fibroblasts from long-lived species of mammals and birds show delayed, but prolonged, phosphorylation of ERK.Aging cell · 2014Article
- Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle.Biochimica et biophysica acta · 2013Review
- Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain.Human molecular genetics · 2013Article
- Somatotropic signaling: trade-offs between growth, reproductive development, and longevity.Physiological reviews · 2013Review
- Decreased thyroid follicle size in dwarf mice may suggest the role of growth hormone signaling in thyroid growth regulation.Thyroid research · 2012Article
- Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress.Aging cell · 2012Article
- Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney-potential mechanism of lifespan extension.Age (Dordrecht, Netherlands) · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Skin-derived fibroblasts from long-lived mutant mice, including the Snell dwarf mice and mice defective in growth hormone receptor (GHRKO mice), are resistant to death induced by oxidative stress or by UV light, but the molecular mechanism for their stress resistance is unknown. This study shows that phosphorylation of the stress-activated protein kinases ERK1/2 induced by peroxide, cadmium, or paraquat is attenuated in cells from these mice. Induction of ERK phosphorylation by UV light was not altered in the Snell dwarf cells, and neither JNK nor p38 kinase showed increased phosphorylation in response to any of the stresses tested. Surprisingly, stress-induced elevation of mRNA for certain immediate early genes (Egr-1 and Fos) was higher in Snell-derived cells than in control cells, despite the evidence of lower ERK phosphorylation. Thus cells from Snell dwarf mice differ from controls in two ways: (a) lower induction of ERK1/2 phosphorylation and (b) increased expression of some ERK-dependent immediate early genes. These alterations in kinase pathways may contribute to the resistance of these cells to lethal injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.