ReviewExperimental neurology2009
Huntington's disease: silencing a brutal killer.
Review in Experimental neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Brain Alterations in Aged OVT73 Sheep Model of Huntington's Disease: An MRI Based Approach.Journal of Huntington's disease · 2022Article
- Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.Nucleic acids research · 2021Article
- Regulatory and Scientific Advancements in Gene Therapy: State-of-the-Art of Clinical Applications and of the Supporting European Regulatory Framework.Frontiers in medicine · 2017Review
- State-of-the-art human gene therapy: part II. Gene therapy strategies and clinical applications.Discovery medicine · 2014Review
- Prospects for neuroprotective therapies in prodromal Huntington's disease.Movement disorders : official journal of the Movement Disorder Society · 2014Review
- Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
- A natural antisense transcript at the Huntington's disease repeat locus regulates HTT expression.Human molecular genetics · 2011Article
- Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism.Chemistry & biology · 2010Article
- Targeting individual calpain isoforms for neuroprotection.Experimental neurology · 2010Article
- Huntington's disease: progress toward effective disease-modifying treatments and a cure.Human molecular genetics · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.