ReviewCurrent psychiatry reports2009
The genetics of alcoholism.
Review in Current psychiatry reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 69 citations in OpenAlex.
- Catechol-O-methyltransferase (COMT) Val158Met Polymorphism and Susceptibility to Alcohol Dependence.Indian journal of clinical biochemistry : IJCB · 2021Review
- The Development of Kraepelin's Mature Diagnostic Concept of Catatonic Dementia Praecox: A Close Reading of Relevant Texts.Schizophrenia bulletin · 2020Article
- Genetic variation in health insurance coverage.International journal of health economics and management · 2019Article
- Article
- Prevention, Use of Health Services, and Genes: Implications of Genetics for Policy Formation.Journal of policy analysis and management : [the journal of the Association for Public Policy Analysis and Management] · 2015Article
- Rasgrf2 controls noradrenergic involvement in the acute and subchronic effects of alcohol in the brain.Psychopharmacology · 2014Article
- Fetal Alcohol Spectrum Disorders: Recent Neuroimaging Findings.Current developmental disorders reports · 2014Article
- Moderators of the association between peer and target adolescent substance use.Addictive behaviors · 2014Review
- Stress and development of depression and heavy drinking in adulthood: moderating effects of childhood trauma.Social psychiatry and psychiatric epidemiology · 2013Article
- Episodic memories and their relevance for psychoactive drug use and addiction.Frontiers in behavioral neuroscience · 2013Article
- Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1.Neuropharmacology · 2012Article
- Translational behaviour-genetic studies of alcohol: are we there yet?Genes, brain, and behavior · 2012Review
- How does the social environment 'get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology.Social science & medicine (1982) · 2012Review
- Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Alcoholism, clinical and experimental research · 2011Article
- Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model.Alcoholism, clinical and experimental research · 2010Review
- Binge drinking effects on EEG in young adult humans.International journal of environmental research and public health · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Heritability estimates for alcoholism range from 50% to 60%, pointing out the importance of genetic and environmental factors in its etiology. This review highlights recent advances in translational work investigating genetic influences on alcoholism. We focus on genetic research involving corticotropin-releasing factor, glutamatergic, and opioidergic systems. Variation in the CRF1 receptor gene has been shown to moderate stress-induced alcohol drinking (gene-environment interaction) in animals, and this finding was recently extended to humans. Also, the hyperglutamatergic state, first observed during withdrawal from chronic alcohol exposure in animal models, is associated with aversive and dysphoric states in alcoholics. Pharmacogenetic studies of naltrexone efficacy are in the clinical stages, and recent studies confirmed a differential response dependent on the mu-opioid receptor genotype. Such advances will be essential for the effective treatment of alcoholism in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.