ArticleProteome science2009
2-DE analysis indicates that Acinetobacter baumannii displays a robust and versatile metabolism.
Article in Proteome science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Metabolic versatility ofFrontiers in microbiology · 2026Article
- 'GGFGGQ' repeats in Hfq of Acinetobacter baumannii are essential for nutrient utilization and virulence.The Journal of biological chemistry · 2024Article
- Biochemical and structural elucidation of the L-carnitine degradation pathway of the human pathogenFrontiers in microbiology · 2024Article
- The novel two-component system AmsSR governs alternative metabolic pathway usage inFrontiers in microbiology · 2023Article
- Fluorescence-Based Detection of Natural Transformation in Drug-Resistant Acinetobacter baumannii.Journal of bacteriology · 2018Article
- The Hyr1 protein from the fungus Candida albicans is a cross kingdom immunotherapeutic target for Acinetobacter bacterial infection.PLoS pathogens · 2018Article
- A Commensal Strain of Staphylococcus epidermidis Overexpresses Membrane Proteins Associated with Pathogenesis When Grown in Biofilms.The Journal of membrane biology · 2015Article
- Quantitative proteomic analysis of host--pathogen interactions: a study of Acinetobacter baumannii responses to host airways.BMC genomics · 2015Article
- Quantitative proteomics to study carbapenem resistance in Acinetobacter baumannii.Frontiers in microbiology · 2014Review
- Proteomic analysis of Fusarium oxysporum f. sp. cubense tropical race 4-inoculated response to Fusarium wilts in the banana root cells.Proteome science · 2013Article
- Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?Clinical microbiology reviews · 2013Review
- Comparative proteomics of inner membrane fraction from carbapenem-resistant Acinetobacter baumannii with a reference strain.PloS one · 2012Article
- Active and passive immunization protects against lethal, extreme drug resistant-Acinetobacter baumannii infection.PloS one · 2012Article
- Horizontal transfer of the OXA-24 carbapenemase gene via outer membrane vesicles: a new mechanism of dissemination of carbapenem resistance genes in Acinetobacter baumannii.Antimicrobial agents and chemotherapy · 2011Article
- Deciphering the iron response in Acinetobacter baumannii: A proteomics approach.Journal of proteomics · 2011Article
- A rapid and simple method for constructing stable mutants of Acinetobacter baumannii.BMC microbiology · 2010Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcinetobacter baumannii is a nosocomial pathogen that has been associated with outbreak infections in hospitals. Despite increasing awareness about this bacterium, its proteome remains poorly characterised, however recently the complete genome of A. baumannii reference strain ATCC 17978 has been sequenced. Here, we have used 2-DE and MALDI-TOF/TOF approach to characterise the proteome of this strain.
resultsThe membrane and cytoplasmatic protein extracts were analysed separately, these analyses revealed the reproducible presence of 239 and 511 membrane and cytoplamatic protein spots, respectively. MALDI-TOF/TOF characterisation identified a total of 192 protein spots (37 membrane and 155 cytoplasmatic) and revealed that the identified membrane proteins were mainly transport-related proteins, whereas the cytoplasmatic proteins were of diverse nature, although mainly related to metabolic processes.
conclusionThis work indicates that A. baumannii has a versatile and robust metabolism and also reveal a number of proteins that may play a key role in the mechanism of drug resistance and virulence. The data obtained complements earlier reports of A. baumannii proteome and provides new tools to increase our knowledge on the protein expression profile of this pathogen.
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