ArticleThe British journal of dermatology2009
Th17/Tc17 infiltration and associated cytokine gene expression in elicitation phase of allergic contact dermatitis.
Article in The British journal of dermatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 98 citations in OpenAlex.
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- A short-term high-sugar diet is an aggravating factor in experimental allergic contact dermatitis.Heliyon · 2023Article
- Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response.Scientific reports · 2023Article
- Mouse CCL9 Chemokine Acts as Tumor Suppressor in a Murine Model of Colon Cancer.Current issues in molecular biology · 2023Article
- Obesity aggravates contact hypersensitivity reaction in mice.Contact dermatitis · 2022Article
- Models of Dendritic Cells to Assess Skin Sensitization.Frontiers in toxicology · 2022Article
- Intricate Relationship Between Adaptive and Innate Immune System in Allergic Contact Dermatitis.The Yale journal of biology and medicine · 2020Review
- Article
- Levels of Tc17 cells in thymic epithelial cell tumors associated with autoimmune diseases.Mediastinum (Hong Kong, China) · 2019Article
- The Role and Diagnosis of Allergic Contact Dermatitis in Patients with Atopic Dermatitis.American journal of clinical dermatology · 2018Review
- Prostaglandin EThe Journal of allergy and clinical immunology · 2018Article
- Mast cells acquire MHCII from dendritic cells during skin inflammation.The Journal of experimental medicine · 2017Article
- CXCR4 inhibitor attenuates ovalbumin-induced airway inflammation and hyperresponsiveness by inhibiting Th17 and Tc17 cell immune response.Experimental and therapeutic medicine · 2016Article
- IL-17 producing mast cells promote the expansion of myeloid-derived suppressor cells in a mouse allergy model of colorectal cancer.Oncotarget · 2015Article
- Titanium allergy: a literature review.Indian journal of dermatology · 2014Review
- IL-9 regulates allergen-specific Th1 responses in allergic contact dermatitis.The Journal of investigative dermatology · 2014Article
- IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-α, interferon-γ and interleukin-12.Immunology · 2013Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAllergic contact dermatitis (ACD) is a typical delayed-type hypersensitivity to sensitizing haptens mediated by T cells. Th1/Tc1 cells are currently considered to be the primary effectors in ACD. There is little information concerning the role played in ACD in humans by Th17/Tc17 cells, a recently defined subpopulation of effector T cells.
objectivesIn the present report we attempted to characterize Th17/Tc17 cells in the infiltrates of the skin in the elicitation phase of ACD.
methodsTh17 as well as Th1/Th2 cytokine gene expression was examined by semiquantitative real-time polymerase chain reaction in paired samples of positive patch test biopsies and normal skin from 11 patients allergic to nine different allergens. The in situ characterization of interleukin (IL)-17-producing cells was carried out using anti-RORC and anti-T-cell subset antibodies by double immunofluorescence.
resultsCompared with normal paired skin samples, gene expression of transcription factor for human Th17 cells, RORC, and Th17-related cytokines IL-17A, IL-17F and IL-23 was significantly increased in positive patch test biopsies. The mRNA for interferon-gamma and IL-4 was also increased. In the dermal infiltrates, about 20% of the infiltrating cells were IL-17-producing cells as they expressed RORC, and such RORC-expressing cells were detected in both CD4+ (approximately 30%) and CD8+ (approximately 20%) subsets.
conclusionsThis is the first demonstration of Th17/Tc17 cells in the elicitation phase of human ACD, showing that they are a regular participant in the immunopathology of this common allergic reaction regardless of the nature of the triggering allergen.
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