ArticleEuropean journal of immunology2009
CD46-induced human Treg enhance B-cell responses.
Article in European journal of immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- CHAPLE-Like Enteropathy and Renal Microangiopathy in an Adult Patient With CD46 Deficiency.Journal of clinical laboratory analysis · 2026Article
- Atypical hemolytic uremic syndrome: genetically-based insights into pathogenesis through an analysis of the complement regulator CD46.Annals of blood · 2023Article
- Prenatal stress, anxiety and depression alter transcripts, proteins and pathways associated with immune responses at the maternal-fetal interface†.Biology of reproduction · 2022Article
- Highly efficient CRISPR-Cas9-mediated gene knockout in primary human B cells for functional genetic studies of Epstein-Barr virus infection.PLoS pathogens · 2021Article
- Neonatal priming and infancy boosting with a novel respiratory syncytial virus vaccine induces protective immune responses without concomitant respiratory disease upon RSV challenge.Human vaccines & immunotherapeutics · 2020Article
- Impaired tumor necrosis factor-α secretion by CD4 T cells during respiratory syncytial virus bronchiolitis associated with recurrent wheeze.Immunity, inflammation and disease · 2020Article
- Complement receptor CD46 co-stimulates optimal human CD8Nature communications · 2018Article
- Environmental peer pressure: CD4Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2018Review
- Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus.European journal of immunology · 2017Article
- Genome-wide associations of CD46 and IFI44L genetic variants with neutralizing antibody response to measles vaccine.Human genetics · 2017Article
- CD4Hepatology (Baltimore, Md.) · 2017Article
- Characterization of the Regulation of CD46 RNA Alternative Splicing.The Journal of biological chemistry · 2016Article
- Therapeutic potential of regulatory cytokines that target B cells.International immunology · 2016Review
- Incomplete penetrance of CD46 mutation causing familial atypical hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2015Article
- Complement regulator CD46: genetic variants and disease associations.Human genomics · 2015Review
- TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.Nature communications · 2015Article
- The CD46-Jagged1 interaction is critical for human TH1 immunity.Nature immunology · 2012Article
- 1α,25-dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells.Thorax · 2012Article
- Regulatory T cell-mediated control of autoantibody-induced inflammation.Frontiers in immunology · 2012Article
- CD46 in innate and adaptive immunity: an update.Clinical and experimental immunology · 2011Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Regulatory CD4(+) T cells (Treg) are important modulators of the immune response. Different types of Treg have been identified based on whether they are thymically derived (natural Treg) or induced in the periphery (adaptive Treg). We recently reported on an adaptive Treg phenotype that can be induced by the concomitant stimulation of human CD4(+) T cells through CD3 and the membrane complement regulator CD46. These complement (CD46)-induced regulatory T cells (cTreg) potently inhibit bystander T-cell proliferation through high-level secretion of IL-10. In addition, cTreg express granzyme B and exhibit cytotoxic effects toward activated effector T cells. Here, we analyzed the effect of cTreg on B-cell functions in a co-culture system. We found that cTreg enhance B-cell Ab production. This B-cell support is dependent on cell/cell contact as well as cTreg-derived IL-10. In addition, we show that T cells from a CD46-deficient patient are not capable of promoting B-cell responses, whereas CD46-deficient B cells have no intrinsic defect in Ig production. This finding may relate to a subset of CD46-deficient patients, who present with common variable immunodeficiency. Thus, the lack of cTreg function in optimizing B-cell responses could explain why some CD46-deficient patients develop common variable immunodeficiency.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.