ArticleCancer causes & control : CCC2010
Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot study.
Article in Cancer causes & control : CCC, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The association between telomere length and cancer risk in population studies.Scientific reports · 2016Pooled it
- The association of telomere length and cancer: a meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2011Pooled it
- Shortened telomere length is associated with increased risk of cancer: a meta-analysis.PloS one · 2011Pooled it
- Telomere length, genetic variants and risk of squamous cell carcinoma of the head and neck in Southeast Chinese.Scientific reports · 2016Trial
- The Bidirectional Role of Cellular Senescence in the Treatment of Ovarian Cancer.Biomedicines · 2026Review
- Telomere length and chronotype among women in the California Teachers Study (CTS).Chronobiology international · 2024Article
- Telomere length and hTERT genetic variants as potential prognostic markers in multiple myeloma.Scientific reports · 2023Article
- Role of telomere length in human carcinogenesis (Review).International journal of oncology · 2023Review
- Maternal age at last birth and leukocyte telomere length in a nationally representative population of perimenopausal and postmenopausal women.Menopause (New York, N.Y.) · 2020Article
- Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant Tumors.Cancers · 2020Article
- Altered expression of telomere-associated genes in leukocytes among BRCA1 and BRCA2 carriers.Molecular carcinogenesis · 2018Article
- Review
- Chromosome Abnormalities and Absolute Telomere Lengths of Leukocytes from Silk Weavers with Emphasis on Potential Genotoxicity and Mutagenicity of Silk DyesAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Beginning at the ends: telomeres and human disease.F1000Research · 2018Review
- Social-demographics, health behaviors, and telomere length in the Mexican American Mano a Mano Cohort.Oncotarget · 2017Article
- Telomere length, ATM mutation status and cancer risk in Ataxia-Telangiectasia families.Carcinogenesis · 2017Article
- Physical activity and telomere length: Impact of aging and potential mechanisms of action.Oncotarget · 2017Review
- Genetic variants in telomere-maintenance genes are associated with ovarian cancer risk and outcome.Journal of cellular and molecular medicine · 2017Article
- Prediagnosis Leukocyte Telomere Length and Risk of Ovarian Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Identification of recurrent focal copy number variations and their putative targeted driver genes in ovarian cancer.BMC bioinformatics · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesTelomeres are structures at chromosome ends that contribute to maintaining genomic integrity. Telomere shortening with repeated cell divisions may lead to genomic instability and carcinogenesis. Studies suggest that shorter telomeres in constitutional DNA are associated with bladder, breast, lung, and renal cancer. Ovarian cancer tissues also have shortened telomeres and increased telomerase activity, suggesting that telomere abnormalities may be related to ovarian cancer.
methodsWe investigated leukocyte telomere length in 99 women with serous ovarian adenocarcinoma and 100 age-matched cancer-free controls enrolled in a population-based case-control study.
resultsCases tended to have shorter telomeres than controls (P (wilcoxon) = 0.002). Compared to subjects with telomere lengths in the longest tertile, those in the middle and shortest tertiles showed respective age-adjusted odds ratios (95% confidence intervals) of 2.69 (1.23-5.88) and 3.39 (1.54-7.46) (P (trend) = 0.002). Strongest associations were found for subjects with poorly differentiated carcinomas (OR = 4.89, 95% CI 1.93-12.34).
conclusionsThis study shows that short leukocyte telomeres are associated with serous ovarian adenocarcinoma. These findings should be confirmed in large, prospective studies.
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