ArticleJournal of industrial microbiology & biotechnology2009
Improved simultaneous production of mycelial biomass and polysaccharides by submerged culture of Hericium erinaceum: optimization using a central composite rotatable design (CCRD).
Article in Journal of industrial microbiology & biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Optimization of chemical conditions for metabolites production byFrontiers in microbiology · 2023Article
- Antioxidant activity and cytotoxicity of exopolysaccharide from mushroomBiomass conversion and biorefinery · 2022Article
- Production, medium optimization, and structural characterization of an extracellular polysaccharide produced byFood science & nutrition · 2020Article
- Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas LigandFrontiers in pharmacology · 2019Article
- A proteomics approach to identifying novel protein targets involved in erinacine A-mediated inhibition of colorectal cancer cells' aggressiveness.Journal of cellular and molecular medicine · 2017Article
- Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans.Foods (Basel, Switzerland) · 2016Review
- Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade.Journal of translational medicine · 2016Article
- Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine.International journal of molecular sciences · 2014Article
- Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats.BMC complementary and alternative medicine · 2013Article
- Article
- Optimization and scale-up of 2,3-butanediol production by Bacillus amyloliquefaciens B10-127.World journal of microbiology & biotechnology · 2012Article
- Optimization of culture conditions to produce high yields of active Acetobacter sp. CCTCC M209061 cells for anti-Prelog reduction of prochiral ketones.BMC biotechnology · 2011Article
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Authors and funding
4 authors.
Funding
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Abstract
The aim of this study was to optimize the culture medium used for the mycelial growth and production of intracellular polysaccharides (IPS) and exopolysaccharides (EPS) in a submerged culture of Hericium erinaceum. Of the various factors examined, including carbon and nitrogen sources, vitamins, mineral elements, and initial pH, those that proved to have a significant effect were then tested using a 2(4) central composite rotatable design (CCRD). Under the optimal culture conditions, the maximal yield of biomass reached 14.24 +/- 0.45 g l(-1) and was 1.85-fold higher than in the basal medium. The kinetics of EPS biosynthesis in a bioreactor showed that although the highest yield of EPS (2.75 +/- 0.27 g l(-1)) could be obtained on day 8, the process of biosynthesizing high molecular weight polysaccharides proceeded until the depletion of the carbon source in the medium (after 14 days of cultivation). Our results could be very helpful in the large-scale production of bioactive polysaccharides from H. erinaceum.
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