ArticleHeart and vessels2009
Prognostic value of interleukin-6 during a 3-year follow-up in patients with acute ST-segment elevation myocardial infarction.
Article in Heart and vessels, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Beneficial effect of polaprezinc on cardiac function post-myocardial infarction: A prospective and randomized clinical trial.Medicine · 2019Trial
- Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Trial
- Trial
- CD14 and IL6 polymorphisms are associated with a pro-atherogenic profile in young adults with acute myocardial infarction.Journal of thrombosis and thrombolysis · 2013Trial
- Acute myocardial infarction and cardiogenic shock: prognostic impact of cytokines: INF-γ, TNF-α, MIP-1β, G-CSF, and MCP-1β.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2012Trial
- Cilostazol reduces the progression of carotid intima-media thickness without increasing the risk of bleeding in patients with acute coronary syndrome during a 2-year follow-up.Heart and vessels · 2011Trial
- The Influence of Treatment with PCSK9 Inhibitors and Variants in theJournal of cardiovascular development and disease · 2022Article
- High levels of interleukin-6 are associated with final infarct size and adverse clinical events in patients with STEMI.Open heart · 2021Article
- Causes and consequences of cardiac fibrosis in patients referred for surgical aortic valve replacement.ESC heart failure · 2019Article
- Expression profiles of long noncoding RNAs and messenger RNAs in the border zone of myocardial infarction in rats.Cellular & molecular biology letters · 2019Article
- Article
- Circulating Levels of IL-6 Receptor and gp130 and Long-Term Clinical Outcomes in ST-Elevation Myocardial Infarction.Journal of the American Heart Association · 2016Observational
- Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock.Clinical research in cardiology : official journal of the German Cardiac Society · 2012Article
- Altered gene expression pattern in peripheral blood mononuclear cells in patients with acute myocardial infarction.PloS one · 2012Article
- Inflammation and hypertension: the interplay of interleukin-6, dietary sodium, and the renin-angiotensin system in humans.American journal of hypertension · 2011Article
- Impact of serum high-mobility group box 1 protein elevation on oxygenation impairment after thoracic aortic aneurysm repair.Heart and vessels · 2011Article
- Association of serum levels of arachidonic acid and eicosapentaenoic acid with prevalence of major adverse cardiac events after acute myocardial infarction.Heart and vessels · 2011Article
- Study on the relationship of cPLA2, CK-MB, and membrane phospholipid content in acute myocardial infarction.Heart and vessels · 2011Article
- Association between the interleukin-6 promoter polymorphism -174G/C and serum lipoprotein(a) concentrations in humans.PloS one · 2011Article
- Data feedback reduces door-to-balloon time in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention.Heart and vessels · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence suggests that inflammation plays an essential role in the pathogenesis of atherosclerosis. This recognition has stimulated the evaluation of different inflammatory markers as potential predictors of cardiovascular risk. However, the existing data are limited and controversial. This study was designed to simultaneously measure serum levels of interleukin-6 (IL-6), soluble CD40 ligand (sCD40L), metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with acute ST segment elevation myocardial infarction (STEMI) and to evaluate their ability to predict prognosis. A prospective cohort study was conducted with 263 patients with first STEMI who were admitted to our institute within 6 h of symptoms onset. Clinical data were recorded and serum admission levels of IL-6, sCD40L, MMP-9, and TIMP-1 were measured by sandwich enzyme-linked immunosorbent assay. The patients were then followed prospectively for the occurrence of cardiovascular mortality for 3 years. Follow-up information was available for 228 patients (86.7%) from the 263 STEMI patients; 34 patients died from cardiovascular causes during the 3-year follow-up period. Kaplan-Meier plots demonstrated a significant increase in cardiovascular mortality with increasing IL-6 levels (chi(2) = 14.13, P = 0.0002, by log-rank test). Logistic regression analysis revealed that IL-6 was an independent predictor for cardiovascular mortality. The present study indicates that elevated admission level of IL-6 could provide valuable information for long-term risk stratification in patients with STEMI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.