ArticleJournal of molecular histology2009
Expression of gap junctional protein connexin43 during 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis.
Article in Journal of molecular histology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Models of Oral Epithelial Dysplasia: A Systematic Review and Temporal Analysis.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Pooled it
- Targeted repair of oral mucosal injury: emerging applications of biomaterials-based drug delivery systems.Journal of nanobiotechnology · 2026Review
- Connexin subtype expression during oral carcinogenesis: A pilot study in patients with oral squamous cell carcinoma.Molecular and clinical oncology · 2016Article
- All-trans retinoic acid restores gap junctional intercellular communication between oral cancer cells with upregulation of Cx32 and Cx43 expressions in vitro.Medicina oral, patologia oral y cirugia bucal · 2013Article
- Expressions of CXCR7/ligands may be involved in oral carcinogenesis.Journal of molecular histology · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral carcinogenesis is a multistep process and requires accumulation and interplay of a series of molecular genetic events. Gap junctions are intercellular channels composed of connexin subunits that mediate cell-cell communication. The disfunctions of gap junctions are believed to be associated with cancer development. We therefore investigated the expression of connexin (Cx)43, one of the major connexins in oral epithelia, during 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis. By immunohistochemistry, Cx43 expression was observed mainly in the cell membrane in normal rat oral epithelia. It was weak in the basal cell layer, increased in the stratum spinosum and stratum granulosum, and negative in the stratum corneum of normal epithelia. Throughout the course of carcinogenesis, both Cx43 immunostained area and mean intensity decreased with significant difference among various histopathological groups (P < 0.05). In cancerous oral epithelia cytoplasmic staining could be observed. However, Cx43 mRNA level showed no significant difference in the progress of oral carcinogenesis (P > 0.05) and without correlation to Cx43 protein immunostained area and mean intensity. Our results indicated that downregulation of Cx43 might be an early event during oral carcinogenesis, which could be a biomarker for early changes in oral malignant transformation.
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Registered trials
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