Trial reportBulletin of the World Health Organization2009
Integrated malaria vector control with microbial larvicides and insecticide-treated nets in western Kenya: a controlled trial.
Trial report in Bulletin of the World Health Organization, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
143 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Vector borne disease control interventions in agricultural and irrigation areas in sub-Saharan Africa: A systematic review.PloS one · 2025Pooled it
- Integrated malaria prevention in low- and middle-income countries: a systematic review.Malaria journal · 2023Pooled it
- Larviciding to prevent malaria transmission.The Cochrane database of systematic reviews · 2019Pooled it
- Mosquito larval source management for controlling malaria.The Cochrane database of systematic reviews · 2013Pooled it
- High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial.Scientific reports · 2021Trial
- Trial
- A randomized trial of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated malaria among children in western Kenya.Malaria journal · 2013Trial
- Trial
- Article
- Review
- A large-scale mosquito larviciding in Tanga Region, Tanzania, reduced mosquito densities to varying degrees across malaria transmission risk strata.Scientific reports · 2025Article
- Utilization of vector bionomics, remote sensing and larval habitat characterization data to inform larval source management decision in the high malaria burden state of Kebbi, Nigeria.Malaria journal · 2025Article
- Integrated vector management for malaria control: a review of approaches and effectiveness.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025Review
- Large-scale intermittent larviciding intervention and associations with key malaria epidemiological parameters in Tanga Region, Tanzania.Malaria journal · 2025Article
- Heterogeneous impacts for malaria control from larviciding across villages and considerations for monitoring and evaluation.PLoS pathogens · 2025Article
- Evaluation of the effectiveness of Aquatain, Bacillus thuringiensis var. israelensis, and Temephos on Anopheles arabiensis and Anopheles stephensi larvae in the laboratory and field settings.Parasites & vectors · 2025Article
- Elevating larval source management as a key strategy for controlling malaria and other vector-borne diseases in Africa.Parasites & vectors · 2025Review
- Combined use of long-lasting insecticidal nets and Bacillus thuringiensis israelensis larviciding, a promising integrated approach against malaria transmission in northern Côte d'Ivoire.Malaria journal · 2024Article
- Considerations for first field trials of low-threshold gene drive for malaria vector control.Malaria journal · 2024Review
- Malaria transmission heterogeneity in different eco-epidemiological areas of western Kenya: a region-wide observational and risk classification study for adaptive intervention planning.Malaria journal · 2024Observational
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the contributions of both microbial larvicides and insecticide-treated nets (ITNs) in terms of reducing malaria incidence in an integrated vector management programme in an area moderately endemic for malaria in the western Kenyan highlands.
methodsA pre-post, control group design was used. Larval and adult vector populations were surveyed weekly in six separate valley communities. The incidence of Plasmodium infections in children 6 months to 13 years of age was measured during the long and short rainy seasons each year. Baseline data were collected for 17 months, after which Bacillus-based larvicides were applied weekly to aquatic habitats in three of the valleys for another 19 months. At around the same time the larviciding was initiated, ITNs were introduced gradually into all study communities by the National Malaria Control Programme. The effect of larviciding, ITNs and other determinants of malaria risk was assessed by means of generalized estimating equations.
findingsThe risk of acquiring new parasite infections in children was substantially and independently reduced by ITN use (odds ratio, OR: 0.69; 95% confidence interval, CI: 0.48-0.99) and larvicide application (OR: 0.44; 95% CI: 0.23-0.82), after adjusting for confounders.
conclusionVector control with microbial larvicides enhanced the malaria control achieved with ITNs alone. Anti-larval measures are a promising complement to ITN distribution in the economically important highland areas and similar transmission settings in Africa.
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