ArticleThe Journal of biological chemistry2009
Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- A Compound Heterozygous Mutation of Lipase Maturation Factor 1 is Responsible for Hypertriglyceridemia of a Patient.Journal of atherosclerosis and thrombosis · 2019Article
- Coexpression of novel furin-resistant LPL variants with lipase maturation factor 1 enhances LPL secretion and activity.Journal of lipid research · 2018Article
- Lipase maturation factor 1 affects redox homeostasis in the endoplasmic reticulum.The EMBO journal · 2018Article
- We FRET so You Don't Have To: New Models of the Lipoprotein Lipase Dimer.Biochemistry · 2018Article
- Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism.Atherosclerosis · 2017Review
- Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling.The Journal of biological chemistry · 2014Article
- Purification, cellular levels, and functional domains of lipase maturation factor 1.Biochemical and biophysical research communications · 2014Article
- Embryonic viability, lipase deficiency, hypertriglyceridemia and neonatal lethality in a novel LMF1-deficient mouse model.Nutrition & metabolism · 2014Article
- Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humans.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Lipase maturation factor 1 is required for endothelial lipase activity.Journal of lipid research · 2011Article
- Genetic determinants of plasma triglycerides.Journal of lipid research · 2011Review
- The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight.Atherosclerosis · 2010Review
- Lipase maturation factor 1: structure and role in lipase folding and assembly.Current opinion in lipidology · 2010Review
- Mechanisms of lipase maturation.Clinical lipidology · 2010Article
Corrections and comments
- Retraction · 2019-08-09Concerns/Issues about Results and/or Conclusions · Duplication of/in Image · Falsification/Fabrication of Image ·
- Retracted
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Lipase maturation factor 1 (LMF1) is predicted to be a polytopic protein localized to the endoplasmic reticulum (ER) membrane. It functions in the post-translational attainment of enzyme activity for both lipoprotein lipase and hepatic lipase. By using transmembrane prediction methods in mouse and human orthologs, models of LMF1 topology were constructed and tested experimentally. Employing a tagging strategy that used insertion of ectopic glycan attachment sites and terminal fusions of green fluorescent protein, we established a five-transmembrane model, thus dividing LMF1 into six domains. Three domains were found to face the cytoplasm (the amino-terminal domain and loops B and D), and the other half was oriented to the ER lumen (loops A and C and the carboxyl-terminal domain). This representative model shows the arrangement of an evolutionarily conserved domain within LMF1 (DUF1222) that is essential to lipase maturation. DUF1222 comprises four of the six domains, with the two largest ones facing the ER lumen. We showed for the first time, using several naturally occurring variants featuring DUF1222 truncations, that Lmf1 interacts physically with lipoprotein lipase and hepatic lipase and localizes the lipase interaction site to loop C within DUF1222. We discuss the implication of our results with regard to lipase maturation and DUF1222 domain structure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.