ArticleNucleic acids research2009
Ion-induced folding of a kink turn that departs from the conventional sequence.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Protein cofactors and substrate influence Mg2+-dependent structural changes in the catalytic RNA of archaeal RNase P.Nucleic acids research · 2021Article
- The Kink Turn, a Key Architectural Element in RNA Structure.Journal of molecular biology · 2016Review
- The K-turn motif in riboswitches and other RNA species.Biochimica et biophysica acta · 2014Review
- Structure of a rare non-standard sequence k-turn bound by L7Ae protein.Nucleic acids research · 2014Article
- The k-junction motif in RNA structure.Nucleic acids research · 2014Article
- Hierarchy of RNA functional dynamics.Annual review of biochemistry · 2014Review
- The plasticity of a structural motif in RNA: structural polymorphism of a kink turn as a function of its environment.RNA (New York, N.Y.) · 2013Article
- Basis for ligand discrimination between ON and OFF state riboswitch conformations: the case of the SAM-I riboswitch.RNA (New York, N.Y.) · 2012Article
- Structure and folding of a rare, natural kink turn in RNA with an A*A pair at the 2b*2n position.RNA (New York, N.Y.) · 2012Article
- RNA tertiary interactions in a riboswitch stabilize the structure of a kink turn.Structure (London, England : 1993) · 2011Article
- The influence of the local sequence environment on RNA loop structures.RNA (New York, N.Y.) · 2011Article
- Solution structure of the K-turn and Specifier Loop domains from the Bacillus subtilis tyrS T-box leader RNA.Journal of molecular biology · 2011Article
- A structural database for k-turn motifs in RNA.RNA (New York, N.Y.) · 2010Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Kink turns (k-turns) are important structural motifs that create a sharp axial bend in RNA. Most conform to a consensus in which a three-nucleotide bulge is followed by consecutive G*A and A*G base pairs, and when these G*A pairs are modified in vitro this generally leads to a failure to adopt the k-turn conformation. Kt-23 in the 30S ribosomal subunit of Thermus thermophilus is a rare exception in which the bulge-distal A*G pair is replaced by a non-Watson-Crick A*U pair. In the context of the ribosome, Kt-23 adopts a completely conventional k-turn geometry. We show here that this sequence is induced to fold into a k-turn structure in an isolated RNA duplex by Mg(2+) or Na(+) ions. Therefore, the Kt-23 is intrinsically stable despite lacking the key A*G pair; its formation requires neither tertiary interactions nor protein binding. Moreover, the Kt-23 k-turn is stabilized by the same critical hydrogen-bonding interactions within the core of the structure that are found in more conventional sequences such as the near-consensus Kt-7. T. thermophilus Kt-23 has two further non-Watson-Crick base pairs within the non-canonical helix, three and four nucleotides from the bulge, and we find that the nature of these pairs influences the ability of the RNA to adopt k-turn conformation, although the base pair adjacent to the A*U pair is more important than the other.
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