ArticleDevelopment (Cambridge, England)2009
Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Absence of the primary cilia formation gene Talpid3 impairs muscle stem cell function.Communications biology · 2023Article
- Ihog proteins contribute to integrin-mediated focal adhesions.Science China. Life sciences · 2023Article
- Customized bioreactor enables the production of 3D diaphragmatic constructs influencing matrix remodeling and fibroblast overgrowth.NPJ Regenerative medicine · 2022Article
- Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix.Journal of developmental biology · 2021Article
- Neural tube development depends on notochord-derived sonic hedgehog released into the sclerotome.Development (Cambridge, England) · 2020Article
- Hedgehog Signaling for Urogenital Organogenesis and Prostate Cancer: An Implication for the Epithelial-Mesenchyme Interaction (EMI).International journal of molecular sciences · 2019Review
- Defects in intervertebral disc and spine during development, degeneration, and pain: New research directions for disc regeneration and therapy.Wiley interdisciplinary reviews. Developmental biology · 2019Review
- In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease.Advanced healthcare materials · 2018Review
- miR-133-mediated regulation of the Hedgehog pathway orchestrates embryo myogenesis.Development (Cambridge, England) · 2018Article
- Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal.Nature communications · 2018Article
- Axial and limb muscle development: dialogue with the neighbourhood.Cellular and molecular life sciences : CMLS · 2016Review
- The notochord: structure and functions.Cellular and molecular life sciences : CMLS · 2015Review
- Hanging on for the ride: adhesion to the extracellular matrix mediates cellular responses in skeletal muscle morphogenesis and disease.Developmental biology · 2015Review
- Misexpression of BRE gene in the developing chick neural tube affects neurulation and somitogenesis.Molecular biology of the cell · 2015Article
- Molecular cues for development and regeneration of salivary glands.Histology and histopathology · 2014Review
- Quantitative proteomic analysis of cultured skin fibroblast cells derived from patients with triglyceride deposit cardiomyovasculopathy.Orphanet journal of rare diseases · 2013Article
- Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity.Genes & development · 2012Article
- Regional differences in the expression of laminin isoforms during mouse neural tube development.Matrix biology : journal of the International Society for Matrix Biology · 2011Article
- Skeletal muscle laminin and MDC1A: pathogenesis and treatment strategies.Skeletal muscle · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Basement membranes have essential structural and signalling roles in tissue morphogenesis during embryonic development, but the mechanisms that control their formation are still poorly understood. Laminins are key components of basement membranes and are thought to be essential for initiation of basement membrane assembly. Here, we report that muscle progenitor cells populating the myotome migrate aberrantly in the ventral somite in the absence of sonic hedgehog (Shh) signalling, and we show that this defect is due to the failure to form a myotomal basement membrane. We reveal that expression of Lama1, which encodes laminin alpha1, a subunit of laminin-111, is not activated in Shh(-/-) embryos. Recovery of Lama1 expression or addition of exogenous laminin-111 to Shh(-/-);Gli3(-/-) embryos restores the myotomal basement membrane, demonstrating that laminin-111 is necessary and sufficient to initiate assembly of the myotomal basement membrane. This study uncovers an essential role for Shh signalling in the control of laminin-111 synthesis and in the initiation of basement membrane assembly in the myotome. Furthermore, our data indicate that laminin-111 function cannot be compensated by laminin-511.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.