ArticleProceedings of the National Academy of Sciences of the United States of America1990
Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 169 citations in OpenAlex.
- Pooled it
- Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia.Nature communications · 2020Article
- Chronic eosinophilic leukemia, NOS with t(5;12)(q31;p13)/ETV6-ACSL6 gene fusion: a novel variant of myeloid proliferative neoplasm with eosinophilia.Human pathology (New York) · 2016Article
- Survival regulation of leukemia stem cells.Cellular and molecular life sciences : CMLS · 2016Review
- Article
- Reversible growth factor dependency and autonomy during murine myelomonocytic leukemia induced by oncogenes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Hoxb8 regulates expression of microRNAs to control cell death and differentiation.Cell death and differentiation · 2013Article
- Targeting self-renewal pathways in myeloid malignancies.Cell communication and signaling : CCS · 2013Article
- The colony-stimulating factors and cancer.Nature reviews. Cancer · 2010Review
- Crossing paths: interactions between the cell death machinery and growth factor survival signals.Cellular and molecular life sciences : CMLS · 2010Review
- A conserved role for Hox paralog group 4 in regulation of hematopoietic progenitors.Stem cells and development · 2009Article
- The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis.The Journal of clinical investigation · 2007Article
- Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Folate modulates Hox gene-controlled skeletal phenotypes.Genesis (New York, N.Y. : 2000) · 2004Article
- Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1.Molecular and cellular biology · 2004Article
- Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.Molecular and cellular biology · 2003Article
- Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia.Leukemia · 2002Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In the murine myelomonocytic leukemia WEHI-3B, proviral insertions have induced expression of the Hox-2.4 homeobox gene and the gene for the myeloid growth factor interleukin 3 (IL-3). To assess their potential oncogenic role, normal bone marrow cells were infected with retroviruses bearing the genes for IL-3 or IL-3 plus Hox-2.4. Unlike the IL-3 virus, the IL-3/Hox-2.4 virus was highly leukemogenic. Infected cells expressing both genes exhibited retarded differentiation in vitro, generated myelomonocytic cell lines, and provoked a rapid, transplantable myeloid leukemia in vivo. The oncogenic action of Hox-2.4 appears to derive from its ability to impede the IL-3-driven terminal differentiation of myeloid cells. The results suggest that homeobox genes can regulate key differentiation processes such as self-renewal capacity and that their inappropriate expression can be oncogenic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.