ArticleBiological psychiatry2010
Sensorimotor transformation deficits for smooth pursuit in first-episode affective psychoses and schizophrenia.
Article in Biological psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Associations between smooth pursuit, predictive pursuit, anomalous self-experiences, and psychotic-like experiences.European archives of psychiatry and clinical neuroscience · 2026Article
- Cognitive control in schizophrenia spectrum disorders is associated with long-term movement activity rather than single-bout exercise.European archives of psychiatry and clinical neuroscience · 2026Article
- Improved patient identification by incorporating symptom severity in deep learning using neuroanatomic images in first episode schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis.Scientific reports · 2024Article
- Atypical neural processing during the execution of complex sensorimotor behavior in autism.Behavioural brain research · 2021Article
- Towards Clinically Relevant Oculomotor Biomarkers in Early Schizophrenia.Frontiers in behavioral neuroscience · 2021Article
- Relational memory in the early stage of psychotic bipolar disorder.Psychiatry research · 2020Article
- Cognitive Impairment and Diminished Neural Responses Constitute a Biomarker Signature of Negative Symptoms in Psychosis.Schizophrenia bulletin · 2020Article
- Visual feedback during motor performance is associated with increased complexity and adaptability of motor and neural output.Behavioural brain research · 2019Article
- Free visual exploration of natural movies in schizophrenia.European archives of psychiatry and clinical neuroscience · 2019Article
- Schizotypy and smooth pursuit eye movements as potential endophenotypes of obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2019Article
- Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study.Translational psychiatry · 2017Article
- Visual and non-visual motion information processing during pursuit eye tracking in schizophrenia and bipolar disorder.European archives of psychiatry and clinical neuroscience · 2017Article
- A Cohesive Framework for Motor Stereotypy in Typical and Atypical Development: The Role of Sensorimotor Integration.Frontiers in integrative neuroscience · 2017Article
- Pursuit eye movements as an intermediate phenotype across psychotic disorders: Evidence from the B-SNIP study.Schizophrenia research · 2015Article
- Disease and drug effects on internally-generated and externally-elicited responses in first episode schizophrenia and psychotic bipolar disorder.Schizophrenia research · 2014Article
- Association of variants in DRD2 and GRM3 with motor and cognitive function in first-episode psychosis.European archives of psychiatry and clinical neuroscience · 2014Article
- Smooth pursuit eye movement, prepulse inhibition, and auditory paired stimuli processing endophenotypes across the schizophrenia-bipolar disorder psychosis dimension.Schizophrenia bulletin · 2014Article
- Enhanced top-down control during pursuit eye tracking in schizophrenia.European archives of psychiatry and clinical neuroscience · 2013Article
- Advanced analysis of free visual exploration patterns in schizophrenia.Frontiers in psychology · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundSmooth pursuit deficits are an intermediate phenotype for schizophrenia that may result from disturbances in visual motion perception, sensorimotor transformation, predictive mechanisms, or alterations in basic oculomotor control. Which of these components are the primary causes of smooth pursuit impairments and whether they are impaired similarly across psychotic disorders remain to be established.
methodsFirst-episode psychotic patients with bipolar disorder (n = 34), unipolar depression (n = 24), or schizophrenia (n = 77) and matched healthy participants (n = 130) performed three smooth pursuit tasks designed to evaluate different components of pursuit tracking.
resultsOn ramp tasks, maintenance pursuit velocity was reduced in all three patients groups with psychotic bipolar patients exhibiting the most severe impairments. Open loop pursuit velocity was reduced in psychotic bipolar and schizophrenia patients. Motion perception during pursuit initiation, as indicated by the accuracy of saccades to moving targets, was not impaired in any patient group. Analyses in 138 participants followed for 6 weeks, during which patients were treated and psychotic symptom severity decreased, and no significant change in performance in any group was revealed.
conclusionsSensorimotor transformation deficits in all patient groups suggest a common alteration in frontostriatal networks that dynamically regulate gain control of pursuit responses using sensory input and feedback about performance. Predictive mechanisms appear to be sufficiently intact to compensate for this deficit across psychotic disorders. The absence of significant changes after acute treatment and symptom reduction suggests that these deficits appear to be stable over time.
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