ArticleJournal of pediatric nursing2009
Stress and body mass index each contributes independently to tumor necrosis factor-alpha production in prepubescent Latino children.
Article in Journal of pediatric nursing, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The Relationship between Psychological Stress and Anthropometric, Biological Outcomes: A Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- The Consequences of Foster Care Versus Institutional Care in Early Childhood on Adolescent Cardiometabolic and Immune Markers: Results From a Randomized Controlled Trial.Psychosomatic medicine · 2019Trial
- Cytokine alterations in pediatric internalizing disorders: Systematic review and exploratory multi-variate meta-analysis.Brain, behavior, & immunity - health · 2022Article
- Integrating anthropometric and cardiometabolic health methods in stress, early experiences, and development (SEED) science.Developmental psychobiology · 2021Review
- Adverse childhood experiences and biomarkers of inflammation in a diverse cohort of early school-aged children.Brain, behavior, & immunity - health · 2020Article
- Psychosocial stress and C-reactive protein from mid-adolescence to young adulthood.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Article
- Chronic Stress in Children and Adolescents: A Review of Biomarkers for Use in Pediatric Research.Biological research for nursing · 2018Article
- Early life stress, air pollution, inflammation, and disease: An integrative review and immunologic model of social-environmental adversity and lifespan health.Neuroscience and biobehavioral reviews · 2018Review
- Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype?Development and psychopathology · 2016Article
- Trajectories of relationship stress and inflammatory processes in adolescence.Development and psychopathology · 2016Article
- Adversity in preschool-aged children: Effects on salivary interleukin-1β.Development and psychopathology · 2015Article
- Childhood adversity and inflammatory processes in youth: a prospective study.Psychoneuroendocrinology · 2013Article
- Molecular aspects of COVID-19 and its relationship with obesity and physical activity: a narrative review.Sao Paulo medical journal = Revista paulista de medicinaReview
- Psychological Stress During Childhood and Adolescence and Its Association With Inflammation Across the Lifespan: A Critical Review and Meta-Analysis.Psychological bulletinArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
This investigation extended prior work by determining if stress and body mass index (BMI) contributed independently to tumor necrosis factor-alpha (TNF-alpha) levels among prepubescent Latino children and if sex and family history of type 2 diabetes mellitus (T2DM) modified these relationships. Data were collected in South Florida from 112 nondiabetic school-aged Hispanic children, of whom 43.8% were obese (BMI >/= 95th percentile) and 51.8% presented with a family history of T2DM. Stressful life events were assessed via parental report using a life events scale. Plasma TNF-alpha levels were determined with enzyme-linked immunosorbent assay. The relative contributions of stress and BMI with TNF-alpha levels and the potential interaction effects of sex and family history of T2DM were analyzed with multiple linear regression analyses. Stress and BMI each accounted for a significant proportion of the unique variance associated with TNF-alpha. The association between stress and TNF-alpha was not modified by sex or family history of T2DM. These findings implicate BMI and stress as independent determinants of TNF-alpha (an inflammatory cytokine and adipocytokine) among Latino children. Future investigations should examine the potential roles of exercise, nutritional status, age, and growth hormone in explicating the relationship between TNF-alpha production and psychosocial distress and risk for infection among obese children.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.