ArticleDevelopmental biology2009
Robo2 is required for Slit-mediated intraretinal axon guidance.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Geometry-preserving vector field reconstruction of high-dimensional cell-state dynamics using ddHodge.Nature communications · 2025Article
- Slit2/Robo1 signaling constrains image stabilization responses to preserve ethologically favorable directional asymmetry.Current biology : CB · 2025Article
- Developmental emergence of first- and higher-order thalamic neuron molecular identities.Development (Cambridge, England) · 2024Article
- Human Retinal Ganglion Cells Respond to Evolutionarily Conserved Chemotropic Cues for Intra Retinal Guidance and Regeneration.Stem cells (Dayton, Ohio) · 2023Article
- Ontogenetic rules for the molecular diversification of hypothalamic neurons.Nature reviews. Neuroscience · 2022Review
- Critical Decrease in the Level of Axon Guidance Receptor ROBO1 in Rod Synaptic Terminals Is Followed by Axon Retraction.Investigative ophthalmology & visual science · 2020Article
- Slit2-Robo2 signaling modulates the fibrogenic activity and migration of hepatic stellate cells.Life sciences · 2018Article
- Article
- VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels.Development (Cambridge, England) · 2017Article
- DSCAM promotes axon fasciculation and growth in the developing optic pathway.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Connecting the retina to the brain.ASN neuro · 2014Review
- Uncoupling of EphA/ephrinA signaling and spontaneous activity in neural circuit wiring.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- sfrp1 promotes cardiomyocyte differentiation in Xenopus via negative-feedback regulation of Wnt signalling.Development (Cambridge, England) · 2013Article
- Repulsive axon guidance cues ephrin-A2 and slit3 stop protrusion of the growth cone leading margin concurrently with inhibition of ADF/cofilin and ERM proteins.Cytoskeleton (Hoboken, N.J.) · 2012Article
- Genomic analysis of wig-1 pathways.PloS one · 2012Article
- Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The developing optic pathway has proven one of the most informative model systems for studying mechanisms of axon guidance. The first step in this process is the directed extension of retinal ganglion cell (RGC) axons within the optic fibre layer (OFL) of the retina towards their exit point from the eye, the optic disc. Previously, we have shown that the inhibitory guidance molecules, Slit1 and Slit2, regulate two distinct aspects of intraretinal axon guidance in a region-specific manner. Using knockout mice, we have found that both of these guidance activities are mediated via Robo2. Of the four vertebrate Robos, only Robo1 and Robo2 are expressed by RGCs. In mice lacking robo1 intraretinal axon guidance occurs normally. However, in mice lacking robo2 RGC axons make qualitatively and quantitatively identical intraretinal pathfinding errors to those reported previously in Slit mutants. This demonstrates clearly that, as in other regions of the optic pathway, Robo2 is the major receptor required for intraretinal axon guidance. Furthermore, the results suggest strongly that redundancy with other guidance signals rather than different receptor utilisation is the most likely explanation for the regional specificity of Slit function during intraretinal axon pathfinding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.