ArticleGastroenterology2010
A functional role for CCR6 on proallergic T cells in the gastrointestinal tract.
Article in Gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Memory Generation and Re-Activation in Food Allergy.ImmunoTargets and therapy · 2021Review
- Relevant fecal microbes isolated from mice with food allergy elicited intestinal cytokine/chemokine network and T-cell immune responses.Bioscience of microbiota, food and health · 2020Article
- Modulation of the CCR6-CCL20 Axis: A Potential Therapeutic Target in Inflammation and Cancer.Medicina (Kaunas, Lithuania) · 2018Review
- Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector TThe Journal of allergy and clinical immunology · 2018Article
- Ana o 1 and Ana o 2 cashew allergens share cross-reactive CD4(+) T cell epitopes with other tree nuts.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
- Jug r 2-reactive CD4(+) T cells have a dominant immune role in walnut allergy.The Journal of allergy and clinical immunology · 2015Article
- NOD2 regulates CXCR3-dependent CD8+ T cell accumulation in intestinal tissues with acute injury.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Peyer's patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy.PloS one · 2014Article
- Serum levels of the CC chemokines CCL2, CCL5, and CCL11 in food allergic children with different clinical manifestations.Inflammation · 2013Article
- Mucosal immunology of food allergy.Current biology : CB · 2013Review
- Mucosal immunology of tolerance and allergy in the gastrointestinal tract.Immunologic research · 2012Review
- The biology of chemokines and their receptors.Immunologic research · 2012Review
- Mucosal antibodies in the regulation of tolerance and allergy to foods.Seminars in immunopathology · 2012Review
- T cell homing to epithelial barriers in allergic disease.Nature medicine · 2012Review
- Inside the mucosal immune system.PLoS biology · 2012Article
- Role of mucosal inflammation in eosinophilic esophagitis: review of the literature.ISRN gastroenterology · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND &
aimsCCL20 is a chemokine that regulates the homeostatic and inflammatory trafficking of leukocytes to the small intestine and regulates the development of the gastrointestinal lymphoid architecture. T cells expressing T helper cell (Th) 2 cytokines are critical for experimental food allergy, and we hypothesized that CCL20 is involved in the localization of these cells to the gut.
methodsWe evaluated the role of CCR6 in allergic diarrhea induced by sensitization and oral challenge with ovalbumin (OVA) using CCR6(+/+) and CCR6(-/-) mice.
resultsCCR6(-/-) mice were protected from OVA-induced diarrhea but surprisingly were not impaired in mastocytosis or allergen-specific immunoglobulin E. CCR6(-/-) mice were also protected from T cell-mediated diarrhea induced by anti-CD3 antibody. Allergic diarrhea was associated with an increased expression of Th2 cytokines within the intestinal mucosa that was significantly reduced in CCR6(-/-) mice. Inhibition of lymphocyte homing by treatment with FTY720 did not impair allergic diarrhea, indicating that reactivation of T cells could occur locally within the small intestine. Finally, T-cell transfer studies demonstrated that CCR6 was required both on the transferred T cells and in the recipient mouse to manifest allergic disease in the gastrointestinal tract.
conclusionsThese studies highlight a mast cell- and immunoglobulin E-independent role for CCR6-bearing T cells in the pathogenesis of gastrointestinal allergic disease.
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