ArticleJournal of critical care2010
Acetaminophen has limited antipyretic activity in critically ill patients.
Article in Journal of critical care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02280239 (Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.), which is not on this map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Antipyretic Efficacy of Acetaminophen in the Febrile Intensive Care Unit Patient.
Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Nonpharmacologic approach to minimizing shivering during surface cooling: a proof of principle study.Journal of critical care · 2012Trial
- Fever in Sepsis Revisited: Is a Little Heat What We Need?Open forum infectious diseases · 2025Review
- The antipyretic effectiveness of dipyrone in the intensive care unit: A retrospective cohort study.PloS one · 2022Article
- [Antipyretics in intensive care patients].Der Anaesthesist · 2017Review
- Fever is associated with delayed ventilator liberation in acute lung injury.Annals of the American Thoracic Society · 2013Article
- Early antipyretic exposure does not increase mortality in patients with gram-negative severe sepsis: a retrospective cohort study.Internal and emergency medicine · 2012Article
- Clinical and demographic factors associated with antipyretic use in gram-negative severe sepsis and septic shock.The Annals of pharmacotherapy · 2011Article
- Fever, hyperthermia, and the lung: it's all about context and timing.Transactions of the American Clinical and Climatological Association · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeFever occurs commonly in the critically ill patients and may adversely affect outcome. Acetaminophen is one of the most commonly used antipyretic agents in the intensive care unit; however, there is little evidence that it is effective in this population. The objective of this study was to analyze the antipyretic activity of acetaminophen in critically ill patients. MATERIALS AND
methodsWe performed a retrospective study of medical intensive care unit and surgical intensive care unit patients with systemic inflammatory response syndrome and compared the resolution of fever in the presence and absence of acetaminophen treatment by comparing the absolute reduction in body temperature and the rate of cooling over comparable time frames in fevers that were untreated and those treated with acetaminophen.
resultsWe analyzed 166 febrile episodes (body temperature, >38 degrees C) in 59 patients with systemic inflammatory response syndrome without cancer, neurologic disease, or liver disease. Acetaminophen was administered for 88 of 166 fevers. Febrile episodes in which other antipyretic drugs or external cooling were administered were excluded. The response to acetaminophen was variable, but the absolute temperature reduction was slightly higher (mean, 0.86 versus 0.56 degrees C; P = .0362), and the cooling rate was slightly more rapid (mean, 0.20 versus 0.13 degrees C per hour; P = .0152) in acetaminophen-treated versus untreated fevers. There were no obvious differences between the most and least responsive patients.
conclusionsWe conclude that acetaminophen has significant albeit modest antipyretic activity in critically ill patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.