ArticleNeuropeptides2009
Evidence from knockout mice for distinct implications of neuropeptide-Y Y2 and Y4 receptors in the circadian control of locomotion, exploration, water and food intake.
Article in Neuropeptides, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- PET Imaging of the Neuropeptide Y System: A Systematic Review.Molecules (Basel, Switzerland) · 2022Pooled it
- Improved Chemical and Radiochemical Synthesis of Neuropeptide Y YPharmaceuticals (Basel, Switzerland) · 2024Article
- Accurate locomotor activity profiles of group-housed mice derived from home cage monitoring data.Frontiers in neuroscience · 2024Article
- Metabolic cold adaptation in the Asiatic toad: intraspecific comparison along an altitudinal gradient.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Review
- Article
- Temporal dissociation of phencyclidine: Induced locomotor and social alterations in rats using an automated homecage monitoring system - implications for the 3Rs and preclinical drug discovery.Journal of psychopharmacology (Oxford, England) · 2020Article
- Peroxiredoxin 6 Is a Key Antioxidant Enzyme in Modulating the Link between Glycemic and Lipogenic Metabolism.Oxidative medicine and cellular longevity · 2019Article
- Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools.Journal of neuroscience methods · 2018Article
- Neuropeptide Y receptors: a promising target for cancer imaging and therapy.Regenerative biomaterials · 2015Article
- The homeostatic role of neuropeptide Y in immune function and its impact on mood and behaviour.Acta physiologica (Oxford, England) · 2015Review
- The use of animal models to decipher physiological and neurobiological alterations of anorexia nervosa patients.Frontiers in endocrinology · 2015Review
- Long-term home cage activity scans reveal lowered exploratory behaviour in symptomatic female Rett mice.Behavioural brain research · 2013Article
- NPY Y1 receptors differentially modulate GABAA and NMDA receptors via divergent signal-transduction pathways to reduce excitability of amygdala neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Neuropeptide Y receptors: how to get subtype selectivity.Frontiers in endocrinology · 2013Article
- Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis.Neuropeptides · 2012Review
- Regulation of drug and palatable food overconsumption by similar peptide systems.Current drug abuse reviews · 2011Review
- Therapeutic potential of neuropeptide Y (NPY) receptor ligands.EMBO molecular medicine · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Members of the neuropeptide-Y (NPY) family acting via Y2 and/or Y4 receptors have been proposed to participate in the control of ingestive behaviour and energy homeostasis. Since these processes vary between day and night, we explored the circadian patterns of locomotor, exploratory and ingestive behaviour in mice with disrupted genes for Y2 (Y2-/-) or Y4 (Y4-/-) receptors. To this end, the LabMaster system was used and its utility for the analysis of changes in circadian activity and ingestion caused by gene knockout evaluated. Female animals, aged 27weeks on average, were housed singly in cages fitted with sensors for water and food intake and two infrared frames for recording ambulation and rearing under a 12h light/dark cycle for 4days. Relative to WT animals, diurnal locomotion, exploration, drinking and feeding were reduced, whereas nocturnal locomotion was enhanced in Y2-/- mice. In contrast, Y4-/- mice moved more but ate and drank less during the photophase, while they ate more and explored less during the scotophase. Both Y2-/- and Y4-/- mice weighed more than WT mice. These findings attest to a differential role of Y2 and Y4 receptor signalling in the circadian control of behaviours that balance energy intake and energy expenditure. These phenotypic traits can be sensitively and continuously recorded by the LabMaster system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.