ArticleNeuropharmacology2010
Gender moderates the association between 5-HTTLPR and decision-making under ambiguity but not under risk.
Article in Neuropharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Iowa Gambling Task: Men and Women Perform Differently. A Meta-analysis.Neuropsychology review · 2025Pooled it
- Differential susceptibility effects of theFrontiers in psychiatry · 2025Article
- Anodal Stimulation of the Left DLPFC Increases IGT Scores and Decreases Delay Discounting Rate in Healthy Males.Frontiers in psychology · 2016Article
- Maladaptive decision making and substance use outcomes in high-risk individuals: preliminary evidence for the role of 5-HTTLPR variation.Journal of studies on alcohol and drugs · 2014Article
- Article
- The genetic and environmental etiology of decision-making: a longitudinal twin study.Journal of adolescence · 2013Article
- Genetics of impulse control disorders in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2013Review
- Effects of repeated adolescent stress and serotonin transporter gene partial knockout in mice on behaviors and brain structures relevant to major depression.Frontiers in behavioral neuroscience · 2013Article
- Can common functional gene variants affect visual discrimination in metacontrast masking?PloS one · 2013Article
- Association between the serotonin transporter triallelic genotype and eating problems is moderated by the experience of childhood trauma in women.The International journal of eating disorders · 2012Article
- Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Review
- Association between a serotonin transporter promoter polymorphism (5HTTLPR) and personality disorder traits in a community sample.Journal of psychiatric research · 2011Article
- Contributions of serotonin in addiction vulnerability.Neuropharmacology · 2011Review
- Increased risk-taking behavior in dopamine transporter knockdown mice: further support for a mouse model of mania.Journal of psychopharmacology (Oxford, England) · 2011Article
- Serotonin Transporter (5-HTTLPR) Genotype and Childhood Trauma are Associated with Individual Differences in Decision Making.Frontiers in genetics · 2011Article
- The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Review
- The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies?Translational psychiatry · 2011Article
- Rodent versions of the iowa gambling task: opportunities and challenges for the understanding of decision-making.Frontiers in neuroscience · 2011Article
- Serotonin transporter gene-linked polymorphic region (5-HTTLPR) influences decision making under ambiguity and risk in a large Chinese sample.Neuropharmacology · 2010Article
Corrections and comments
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2 authors.
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Abstract
Decisions made under ambiguity may involve a different genetic architecture than those made under risk. Because gender moderates the effect of genetic polymorphisms on serotonin function and because there are gender differences in decision-making, the present study examined potential gender moderation of associations between polymorphisms in important serotonin system candidate genes (serotonin transporter [SLC6A4] and tryptophan hydroxylase-2 [TPH2]) and performance on a decision-making task (Iowa Gambling Task, IGT) in healthy, adults (N = 188; 62% women). Subjects were genotyped for the well-studied SLC6A4 promoter variant 5-HTTLPR and a TPH2 single nucleotide polymorphism in intron-8 (rs1386438). Genotype at rs1386438 was not associated with performance on the IGT. A significant gender by 5-HTTLPR genotype interaction effect was detected when decision-making was under ambiguity (i.e. the first block of 20 choices), but not under risk (blocks 2-5). Performance on the first block of 20 choices was not correlated with performance on subsequent blocks, supporting the interpretation that early performance on the IGT indexes decision-making under ambiguity, while performance on blocks 2-5 indexes decision-making under risk. These findings suggest that decision-making under ambiguity and risk may have different genetic architectures and that individual differences in decision-making under ambiguity are associated with genetic variation in SLC6A4.
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