ArticleBMC research notes2009
Parallel changes in gene expression in peripheral blood mononuclear cells and the brain after maternal separation in the mouse.
Article in BMC research notes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
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- Molecular pathways underlying lung-brain axis signaling in asthma: Relevance for psychopathology and neuroinflammation.The Journal of allergy and clinical immunology · 2024Article
- Differential Regulation of Tachykinin and Opioid System Gene Expression in Brain and Immune Cells of Chronic Binge Alcohol-Treated Simian Immunodeficiency Virus-Infected Macaques.AIDS research and human retroviruses · 2023Article
- Blood and brain gene expression signatures of chronic intermittent ethanol consumption in mice.PLoS computational biology · 2022Article
- Peripheral proteomic changes after electroconvulsive seizures in a rodent model of non-response to chronic fluoxetine.Frontiers in pharmacology · 2022Article
- Screening of SERT and p11 mRNA Levels in Airline Pilots: A Translational Approach.Frontiers in psychiatry · 2022Article
- Bruton's tyrosine kinase drives neuroinflammation and anxiogenic behavior in mouse models of stress.Journal of neuroinflammation · 2021Article
- Differentially Expressed Circular RNAs in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model.Frontiers in systems neuroscience · 2021Article
- Dopamine perturbation of gene co-expression networks reveals differential response in schizophrenia for translational machinery.Translational psychiatry · 2018Article
- Transcriptomic signatures of schizophrenia revealed by dopamine perturbation in an ex vivo model.Translational psychiatry · 2018Article
- Differential Peripheral Proteomic Biosignature of Fluoxetine Response in a Mouse Model of Anxiety/Depression.Frontiers in cellular neuroscience · 2017Article
- Genetic predisposition and early life experience interact to determine glutamate transporter (GLT1) and solute carrier family 12 member 5 (KCC2) levels in rat hippocampus.Metabolic brain disease · 2016Article
- DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression.Nature communications · 2015Article
- Transcriptome outlier analysis implicates schizophrenia susceptibility genes and enriches putatively functional rare genetic variants.Human molecular genetics · 2015Article
- Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients: a targeted metabolomic study.Journal of translational medicine · 2015Article
- Transcriptome study of differential expression in schizophrenia.Human molecular genetics · 2013Article
- MicroRNAs as biomarkers for CNS disease.Frontiers in molecular neuroscience · 2013Review
- Decreased level of olfactory receptors in blood cells following traumatic brain injury and potential association with tauopathy.Journal of Alzheimer's disease : JAD · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe functional integration of the neuro-, endocrine- and immune-systems suggests that the transcriptome of white blood cells may reflect neuropsychiatric states, and be used as a non-invasive diagnostic indicator. We used a mouse maternal separation model, a paradigm of early adversity, to test the hypothesis that transcriptional changes in peripheral blood mononuclear cells (PBMCs) are paralleled by specific gene expression changes in prefrontal cortex (PFC), hippocampus (Hic) and hypothalamus (Hyp). Furthermore, we evaluated whether gene expression profiles of PBMCs could be used to predict the separation status of individual animals.
findingsMicroarray gene expression profiles of all three brain regions provided substantial evidence of stress-related neural differences between maternally separated and control animals. For example, changes in expression of genes involved in the glutamatergic and GABAergic systems were identified in the PFC and Hic, supporting a stress-related hyperglutamatergic state within the separated group. The expression of 50 genes selected from the PBMC microarray data provided sufficient information to predict treatment classes with 95% accuracy. Importantly, stress-related transcriptome differences in PBMC populations were paralleled by stress-related gene expression changes in CNS target tissues.
conclusionThese results confirm that the transcriptional profiles of peripheral immune tissues occur in parallel to changes in the brain and contain sufficient information for the efficient diagnostic prediction of stress-related neural states in mice. Future studies will need to evaluate the relevance of the predictor set of 50 genes within clinical settings, specifically within a context of stress-related disorders.
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