ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2009
Molecular epidemiology of Clostridium difficile over the course of 10 years in a tertiary care hospital.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01552668 (The Effect of a Twice Daily, 200 mg Dose of Oral Fidaxomicin Compared to Placebo on Risk of Acquiring C. Difficile and Developing C. Difficile Infection), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of a Twice Daily, 200 mg Dose of Oral Fidaxomicin Compared to Placebo on Risk of Acquiring C. Difficile and Developing C. Difficile Infection (CDI) in High Risk Patients
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spatial and temporal analyses to investigate infectious disease transmission within healthcare settings.The Journal of hospital infection · 2014Pooled it
- Relapse versus reinfection: recurrent Clostridium difficile infection following treatment with fidaxomicin or vancomycin.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Trial
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- The changing epidemiology ofAntimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Update on Commonly Used Molecular Typing Methods forMicroorganisms · 2023Review
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- Characterizing metabolic drivers ofFrontiers in pharmacology · 2023Article
- From Nursery to Nursing Home: Emerging Concepts in Clostridioides difficile Pathogenesis.Infection and immunity · 2020Review
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- Carriage and colonization of C. difficile in preterm neonates: A longitudinal prospective study.PloS one · 2019Article
- Point-Counterpoint: Active Surveillance for Carriers of Toxigenic Clostridium difficile Should Be Performed To Guide Prevention Efforts.Journal of clinical microbiology · 2018Article
- Effects of control interventions on Clostridium difficile infection in England: an observational study.The Lancet. Infectious diseases · 2017Observational
- Clinical Utility of Laboratory Detection of Clostridium difficile Strain BI/NAP1/027.Journal of clinical microbiology · 2016Review
- Asymptomatic Clostridium difficile colonization: epidemiology and clinical implications.BMC infectious diseases · 2015Review
- Clostridium difficile PCR Ribotype 018, a Successful Epidemic Genotype.Journal of clinical microbiology · 2015Article
- The epidemiology of Clostridium difficile infection inside and outside health care institutions.Infectious disease clinics of North America · 2015Review
- Community-acquired Clostridium difficile infection: an increasing public health threat.Infection and drug resistance · 2014Review
- Nontoxigenic Clostridium difficile protects hamsters against challenge with historic and epidemic strains of toxigenic BI/NAP1/027 C. difficile.Antimicrobial agents and chemotherapy · 2013Article
- Reply to McDonald.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Recombinational switching of the Clostridium difficile S-layer and a novel glycosylation gene cluster revealed by large-scale whole-genome sequencing.The Journal of infectious diseases · 2013Article
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe molecular epidemiology of endemic and outbreak Clostridium difficile strains across time is not well known.
methodsHindIII restriction endonuclease analysis (REA) typing was performed on available clinical C. difficile isolates from 1982 to 1991.
resultsThe annual incidence of C. difficile infection (CDI) ranged from 3.2 to 9.9 cases per 1000 discharges and was significantly higher in 1982, 1983, 1985, and 1991 (high-incidence years) than in other years (mean standard deviation number of cases for the high- vs the low-incidence years, 121.8 +/-20.4 and 70.0 +/-15.0; P =.002). A total of 696 (76.6%) of 908 C. difficile isolates were available for REA typing over the 10-year period. Large clusters (>or=10 CDI cases in consecutive months) were caused by REA types B1 and B2 in 1982 and 1983, F2 and B1 in 1985, and K1 in 1991 (high-incidence years). Small clusters of 4-9 CDI cases in consecutive months were caused by REA types G1 (1984), Y4 and Y6 (1987), Y2 (1988), L1 (1989), Y1 (1990), and K1 (1991). Current epidemic REA group BI (unrelated to type B1) was isolated 6 times, twice in 1984, 1988, and 1990.
conclusionsYears with a high incidence of CDI were associated with large clusters of specific REA types that changed yearly. The molecular epidemiology of CDI in this hospital was characterized by a wide diversity of C. difficile types and an ever-changing dominance of specific C. difficile types over time. The current epidemic BI group was found sporadically on 6 occasions. A changing CDI molecular epidemiology should be expected in the future.
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