ArticleChemphyschem : a European journal of chemical physics and physical chemistry2009
Structural and viscoelastic properties of actin networks formed by espin or pathologically relevant espin mutants.
Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.The Journal of cell biology · 2026Article
- Two Deafness-Causing Actin Mutations (DFNA20/26) Have Allosteric Effects on the Actin Structure.Biophysical journal · 2016Article
- Two fundamental mechanisms govern the stiffening of cross-linked networks.Biophysical journal · 2015Article
- Viscoelastic cell mechanics and actin remodelling are dependent on the rate of applied pressure.PloS one · 2012Article
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Authors and funding
8 authors.
Funding
Abstract
The structural organization of the cytoskeleton determines its viscoelastic response which is crucial for the correct functionality of living cells. Both the mechanical response and microstructure of the cytoskeleton are regulated on a microscopic level by the local activation of different actin binding and/or bundling proteins (ABPs). Misregulations in the expression of these ABPs or mutations in their sequence can entail severe cellular dysfunctions and diseases. Here, we study the structural and viscoelastic properties of reconstituted actin networks cross-linked by the ABP espin and compare the obtained network properties to those of other bundled actin networks. Moreover, we quantify the impact of pathologically relevant espin mutations on the viscoelastic properties of these cytoskeletal networks.
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