ArticleDigestive diseases and sciences2010
Intestinal ischemic preconditioning after ischemia/reperfusion injury in rat intestine: profiling global gene expression patterns.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Article
- Ischemic Preconditioning-Induced SOCS-1 Protects Rat Intestinal Ischemia Reperfusion Injury via Degradation of TRAF6.Digestive diseases and sciences · 2017Article
- Protective effect of intestinal ischemic preconditioning on ischemia reperfusion-caused lung injury in rats.Inflammation · 2015Article
- Gene expression related to oxidative stress in the heart of mice after intestinal ischemia.Arquivos brasileiros de cardiologia · 2014Article
- Article
- Intestinal ischemia/reperfusion: microcirculatory pathology and functional consequences.Langenbeck's archives of surgery · 2011Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectiveIntestinal ischemia/reperfusion (IR) injury involves activation of inflammatory mediators, mucosal necrosis, ileus, and alteration in a variety of gene products. Ischemic preconditioning (IPC) reduced all the effects of intestinal injury seen in IR. In an effort to investigate the molecular mechanisms responsible for the protective effects afforded by IPC, we sought to characterize the global gene expression pattern in rats subjected to IPC in the setting of IR injury.
methodsRats were randomized into five groups: (1) Sham, (2) IPC only (3) IR, (4) Early IPC + IR (IPC --> IR), and (5) Late IPC + IR (IPC --> 24 h --> IR). At 6 h after reperfusion, ileum was harvested for total RNA isolation, pooled, and analyzed on complementary DNA (cDNA) microarrays with validation using real-time polymerase chain reaction (PCR). Significance Analysis of Microarray (SAM) software was used to determine statistically significant changes in gene expression.
resultsEarly IPC + IR had 5,167 induced and 4 repressed genes compared with the other groups. SAM analysis revealed 474 out of 10,000 genes differentially expressed among the groups. Early and Late IPC + IR had more genes involved in redox hemostasis, the immune/inflammatory response, and apoptosis than either the IPC only or IR alone groups.
conclusionThe transcriptional profile suggests that IPC exerts its protective effects by regulating the gene response to injury in the intestine.
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