Evidence map›Paper›PMID 19779965›Full record

ArticleClinical and experimental medicine2010

Effects of exposure to hyperbaric oxygen on oxidative stress in rats with type II collagen-induced arthritis.

F Nagatomo, N Gu, H Fujino, T Okiura, F Morimatsu, I Takeda, A Ishihara

Abstract read
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In one paragraph

Article in Clinical and experimental medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

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  9. Mild hyperbaric oxygen: mechanisms and effects.The journal of physiological sciences : JPS · 2019
    Review
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  20. Oxygen concentration-dependent oxidative stress levels in rats.Oxidative medicine and cellular longevity · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

F NagatomoLaboratory of Neurochemistry, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, 606-8501, Japan.
N Gu
H Fujino
T Okiura
F Morimatsu
I Takeda
A Ishihara
Kyoto University · JPHimeji Dokkyo University · JPKobe University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arthritis was induced in 9-week-old female Dark Agouti rats by injecting type II collagen. Serum levels of the derivatives of reactive oxygen metabolites (dROMs), which are oxidative stress markers, and C-reactive protein (CRP) in arthritic rats that were exposed to a pressure of 1.25 atmospheres absolute and an oxygen concentration of 36% for 3 weeks (arthritis + HBO group) were compared to those of control rats (control group) and arthritic rats that were not exposed to hyperbaric oxygen (arthritis group). The body weights of the arthritis and arthritis + HBO groups were lower than that of the control group, whereas no difference in the body weight was observed between the arthritis and arthritis + HBO groups. The serum levels of dROMs and CRP in the arthritis group were higher than those in the control and arthritis + HBO groups. No difference in the serum level of CRP was observed between the control and arthritis + HBO groups. These results indicate that the conditions of hyperbaric oxygen exposure used in this study are effective for reducing the levels of reactive oxygen species, which are overproduced during arthritis.

Indexed as

Atmospheric PressureOxidative StressAnimalsArthritisBody WeightCollagen Type IIC-Reactive ProteinFemaleOxygenRatsReactive Oxygen SpeciesCollagen Type IIC-Reactive ProteinOxygenReactive Oxygen Species

Identifiers

PMID19779965
OpenAlexW2168457363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.