Evidence map›Paper›PMID 19779761›Full record

ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2010

Sarcopenia: etiology, clinical consequences, intervention, and assessment.

T Lang, T Streeper, P Cawthon, K Baldwin, D R Taaffe, T B Harris

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06933823 (Dietary Modification Intervention Involving Family Support), which is not on this map. Cited by 319 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
319citing papers in PubMed, 13 pooled it
19.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06933823 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Dietary Modification Intervention Involving Family Support (FamNUTRI) for Managing Sarcopenic Obesity Among Community-dwelling Older Adults: a Pilot Randomized Controlled Trial

TypeinterventionalSponsorThe Hong Kong Polytechnic UniversityRan2025 to 2026Enrolled72ConditionsSarcopenic ObesityArmsDietary modification intervention involving family support, Dietary modification intervention
3 · Its place in the literature

Who cites it

319 citing papers in PubMed, 13 syntheses or guidelines pooled it, 778 citations in OpenAlex.

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  10. Sarcopenia in distal radius fractures: systematic review of the literature and current findings.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2020
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259 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 2 countries.

T LangDepartment of Radiology and Biomedical Imaging, University of California, UCSF, San Francisco, CA 94143-0946, USA. thomas.lang@radiology.ucsf.edu
T Streeper
P Cawthon
K Baldwin
D R Taaffe
T B Harris
California Pacific Medical Center · USNational Institutes of Health · USUniversity of California, Irvine · USUniversity of California, San Francisco · USUniversity of California System · USUniversity of Queensland · AU

Funding

Sarcopenia analysis in NHANESZIAAG004050 · NIA · NATIONAL INSTITUTE ON AGING · PI HARRIS, TAMARA · 2009 to 2014
$620k
6 · The paper itself

Abstract

The aging process is associated with loss of muscle mass and strength and decline in physical functioning. The term sarcopenia is primarily defined as low level of muscle mass resulting from age-related muscle loss, but its definition is often broadened to include the underlying cellular processes involved in skeletal muscle loss as well as their clinical manifestations. The underlying cellular changes involve weakening of factors promoting muscle anabolism and increased expression of inflammatory factors and other agents which contribute to skeletal muscle catabolism. At the cellular level, these molecular processes are manifested in a loss of muscle fiber cross-sectional area, loss of innervation, and adaptive changes in the proportions of slow and fast motor units in muscle tissue. Ultimately, these alterations translate to bulk changes in muscle mass, strength, and function which lead to reduced physical performance, disability, increased risk of fall-related injury, and, often, frailty. In this review, we summarize current understanding of the mechanisms underlying sarcopenia and age-related changes in muscle tissue morphology and function. We also discuss the resulting long-term outcomes in terms of loss of function, which causes increased risk of musculoskeletal injuries and other morbidities, leading to frailty and loss of independence.

Indexed as

AdultAgedAged, 80 and overAgingFemaleHumansMaleMiddle AgedMuscle ContractionMuscle Fibers, SkeletalMuscle ProteinsMuscle, SkeletalNeuromuscular JunctionSarcopeniaYoung AdultMuscle Proteins

Identifiers

PMID19779761
PMCPMC2832869
OpenAlexW2143149622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.