ArticlePloS one2009
Repetitive immunization enhances the susceptibility of mice to peripherally administered prions.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Acute LPS exposure enhances susceptibility to peripheral prion infection.Scientific reports · 2025Article
- Therapeutic Trajectories in Human Prion Diseases.Sub-cellular biochemistry · 2025Review
- The Effects of Immune System Modulation on Prion Disease Susceptibility and Pathogenesis.International journal of molecular sciences · 2020Review
- How do PrPPathogens (Basel, Switzerland) · 2017Review
- The immunobiology of prion diseases.Nature reviews. Immunology · 2013Review
- Prion diseases as transmissible zoonotic diseases.Osong public health and research perspectives · 2013Review
- Article
- Immunization with recombinant prion protein leads to partial protection in a murine model of TSEs through a novel mechanism.PloS one · 2013Article
- Could immunomodulation be used to prevent prion diseases?Expert review of anti-infective therapy · 2012Article
- Immunomodulation for prion and prion-related diseases.Expert review of vaccines · 2010Review
- Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.Science (New York, N.Y.) · 2010Article
- Protein aggregation diseases: pathogenicity and therapeutic perspectives.Nature reviews. Drug discovery · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The susceptibility of humans and animals to prion infections is determined by the virulence of the infectious agent, by genetic modifiers, and by hitherto unknown host and environmental risk factors. While little is known about the latter two, the activation state of the immune system was surmised to influence prion susceptibility. Here we administered prions to mice that were repeatedly immunized by two initial injections of CpG oligodeoxynucleotides followed by repeated injections of bovine serum albumin/alum. Immunization greatly reduced the required dosage of peripherally administered prion inoculum necessary to induce scrapie in 50% of mice. No difference in susceptibility was observed following intracerebral prion challenge. Due to its profound impact onto scrapie susceptibility, the host immune status may determine disease penetrance after low-dose prion exposure, including those that may give rise to iatrogenic and variant Creutzfeldt-Jakob disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.