ArticlePLoS computational biology2009
Conserved expression patterns predict microRNA targets.
Article in PLoS computational biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- Regulation of the MAPK/ERK Pathway by miRNA-27b in Gastric Cancer: Diagnostic Implications and Therapeutic Potential of Aloin.Asia-Pacific journal of clinical oncology · 2025Article
- RFX1 Regulates Immune Microenvironment and Predicts Immunotherapy Response in Colon Cancer: A Multi-Omics and Clinical Analysis.Oncology research · 2025Article
- A Systems Biology Approach to Identify Novel Biomarkers in Progression from Crohn's Disease to Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Computing microRNA-gene interaction networks in pan-cancer using miRDriver.Scientific reports · 2022Article
- An Interaction-Based Method for Refining Results From Gene Set Enrichment Analysis.Frontiers in genetics · 2022Article
- RFX1: a promising therapeutic arsenal against cancer.Cancer cell international · 2021Review
- Network Analyses Predict Small RNAs That Might Modulate Gene Expression in the Testis and Epididymis ofFrontiers in genetics · 2021Article
- Rewiring of gene expression in circulating white blood cells is associated with pregnancy outcome in heifers (Bos taurus).Scientific reports · 2020Article
- Interplay among miR-29 family, mineral metabolism, and gene regulation in Bos indicus muscle.Molecular genetics and genomics : MGG · 2020Article
- Co-expression clustering across flower development identifies modules for diverse floral forms inPeerJ · 2020Article
- Reverse Expression of Aging-Associated Molecules through Transfection of miRNAs to Aged Mice.Molecular therapy. Nucleic acids · 2017Article
- Gene-microRNA network module analysis for ovarian cancer.BMC systems biology · 2016Article
- Integrating genetics and epigenetics in breast cancer: biological insights, experimental, computational methods and therapeutic potential.BMC systems biology · 2015Review
- Principles of miRNA-mRNA interactions: beyond sequence complementarity.Cellular and molecular life sciences : CMLS · 2015Review
- Identification of nuclear-enriched miRNAs during mouse granulopoiesis.Journal of hematology & oncology · 2014Article
- CNN3 is regulated by microRNA-1 during muscle development in pigs.International journal of biological sciences · 2014Article
- Regulation of the unfolded protein response by microRNAs.Cellular & molecular biology letters · 2013Review
- Regulation of angiogenesis by hypoxia: the role of microRNA.Cellular & molecular biology letters · 2013Review
- Molecular mechanisms of peripheral nerve regeneration: emerging roles of microRNAs.Frontiers in physiology · 2013Article
- Identification and Insilico Analysis of Retinoblastoma Serum microRNA Profile and Gene Targets Towards Prediction of Novel Serum Biomarkers.Bioinformatics and biology insights · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
microRNAs (miRNAs) are major regulators of gene expression and thereby modulate many biological processes. Computational methods have been instrumental in understanding how miRNAs bind to mRNAs to induce their repression but have proven inaccurate. Here we describe a novel method that combines expression data from human and mouse to discover conserved patterns of expression between orthologous miRNAs and mRNA genes. This method allowed us to predict thousands of putative miRNA targets. Using the luciferase reporter assay, we confirmed 4 out of 6 of our predictions. In addition, this method predicted many miRNAs that act as expression enhancers. We show that many miRNA enhancer effects are mediated through the repression of negative transcriptional regulators and that this effect could be as common as the widely reported repression activity of miRNAs. Our findings suggest that the indirect enhancement of gene expression by miRNAs could be an important component of miRNA regulation that has been widely neglected to date.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.