ArticleAIDS (London, England)2009
Viral hepatitis is associated with reduced bone mineral density in HIV-infected women but not men.
Article in AIDS (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Osteoporosis and fractures in HIV/hepatitis C virus coinfection: a systematic review and meta-analysis.AIDS (London, England) · 2014Pooled it
- The effect of HIV-hepatitis C co-infection on bone mineral density and fracture: a meta-analysis.PloS one · 2014Pooled it
- Incident fractures in HIV-infected individuals: a systematic review and meta-analysis.AIDS (London, England) · 2013Pooled it
- Bone density and microarchitecture in hepatitis C and HIV-coinfected postmenopausal minority women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Bone Mineral Density Declines Twice as Quickly Among HIV-Infected Women Compared With Men.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Hepatitis C virus coinfection as a risk factor for osteoporosis and fracture.Current opinion in HIV and AIDS · 2016Review
- Increased risk of hip fracture associated with dually treated HIV/hepatitis B virus coinfection.Journal of viral hepatitis · 2015Article
- Structural Bone Deficits in HIV/HCV-Coinfected, HCV-Monoinfected, and HIV-Monoinfected Women.The Journal of infectious diseases · 2015Article
- Risk of hip fracture associated with untreated and treated chronic hepatitis B virus infection.Journal of hepatology · 2014Article
- Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: a cohort study.Annals of internal medicine · 2014Observational
- Prevalence of causes of secondary osteoporosis and contribution to lower bone mineral density in HIV-infected patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Fractures after antiretroviral initiation.AIDS (London, England) · 2012Article
- Risk of hip fracture associated with hepatitis C virus infection and hepatitis C/human immunodeficiency virus coinfection.Hepatology (Baltimore, Md.) · 2012Article
- Dairy calcium intake and lifestyle risk factors for bone loss in hiv-infected and uninfected Mediterranean subjects.BMC infectious diseases · 2012Article
- Care of the human immunodeficiency virus-infected menopausal woman.American journal of obstetrics and gynecology · 2012Review
- Hip bone geometry in HIV/HCV-co-infected men and healthy controls.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Article
- Classical and emerging roles of vitamin D in hepatitis C virus infection.Seminars in liver disease · 2011Review
- Controlled HIV viral replication, not liver disease severity associated with low bone mineral density in HIV/HCV co-infection.Journal of hepatology · 2011Article
- Fracture incidence in HIV-infected women: results from the Women's Interagency HIV Study.AIDS (London, England) · 2010Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveFew studies have examined the impact of viral hepatitis on bone mineral density (BMD), and none have done so among HIV-infected patients. Our objective was to determine whether viral hepatitis was associated with low BMD in HIV.
design: A cross-sectional study among 1237 HIV-infected patients (625 with viral hepatitis).
methodsDual-energy X-ray absorptiometry scans of the lumbar spine and femoral neck were obtained. Clinical data, hepatitis B and C status, and markers of bone metabolism were determined at dual-energy X-ray absorptiometry scanning. Multivariable logistic regression examined the association between hepatitis and low BMD (Z-score < or =-2.0 at the lumbar spine, femoral neck, or both).
resultsMean BMD Z-scores were lower among hepatitis-coinfected women at the lumbar spine {-0.15 versus +0.29; difference = -0.44 [95% confidence Interval (CI) -0.65 to -0.23]; P < 0.001} and femoral neck [-0.64 versus -0.39; difference = -0.25 (95% CI -0.44 to -0.06); P = 0.009] compared with HIV-monoinfected women. No differences in mean BMD Z-scores were observed between coinfected and monoinfected men. After adjustment for age, BMI, duration of HIV, antiretroviral use, physical activity, and smoking, viral hepatitis was associated with low BMD among women (adjusted odds ratio 2.87, 95% CI 1.31-6.29) but not men (adjusted odds ratio 1.19, 95% CI 0.74-1.91). Coinfected women had lower mean parathyroid hormone (60.1 versus 68.1 pg/ml; P = 0.02) but similar mean 25-hydroxyvitamin D (19.1 versus 19.6 ng/ml; P = 0.6) and osteocalcin (3.0 versus 3.2 ng/ml; P = 0.8) concentrations than HIV-monoinfected women.
conclusionViral hepatitis was associated with a higher risk of low BMD among HIV-infected women but not men.
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