ArticleMicrobiology (Reading, England)2009
SLA2 mutations cause SWE1-mediated cell cycle phenotypes in Candida albicans and Saccharomyces cerevisiae.
Article in Microbiology (Reading, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Endocytosis Mediated byMicroorganisms · 2026Article
- Comprehensive Interactome Analysis for the Sole Adenylyl Cyclase Cyr1 of Candida albicans.Microbiology spectrum · 2022Article
- Systematic Metabolic Profiling IdentifiesmSystems · 2022Article
- From Jekyll to Hyde: The Yeast-Hyphal Transition ofPathogens (Basel, Switzerland) · 2021Review
- The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020Review
- A Global Analysis of Kinase Function inFrontiers in cellular and infection microbiology · 2018Article
- Actin and endocytosis in budding yeast.Genetics · 2015Review
- Septins and Generation of Asymmetries in Fungal Cells.Annual review of microbiology · 2015Review
- Motor protein Myo5p is required to maintain the regulatory circuit controlling WOR1 expression in Candida albicans.Eukaryotic cell · 2012Article
- The endocytic adaptor proteins of pathogenic fungi: charting new and familiar pathways.Medical mycology · 2011Review
- Orthologues of the anaphase-promoting complex/cyclosome coactivators Cdc20p and Cdh1p are important for mitotic progression and morphogenesis in Candida albicans.Eukaryotic cell · 2011Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
The early endocytic patch protein Sla2 is important for morphogenesis and growth rates in Saccharomyces cerevisiae and Candida albicans, but the mechanism that connects these processes is not clear. Here we report that growth defects in cells lacking CaSLA2 or ScSLA2 are associated with a cell cycle delay that is influenced by Swe1, a morphogenesis checkpoint kinase. To establish how Swe1 monitors Sla2 function, we compared actin organization and cell cycle dynamics in strains lacking other components of early endocytic patches (Sla1 and Abp1) with those in strains lacking Sla2. Only sla2 strains had defects in actin cables, a known trigger of the morphogenesis checkpoint, yet all three strains exhibited Swe1-dependent phenotypes. Thus, Swe1 appears to monitor actin patch in addition to actin cable function. Furthermore, Swe1 contributed to virulence in a mouse model of disseminated candidiasis, implying a role for the morphogenesis checkpoint during the pathogenesis of C. albicans infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.