ArticlePharmacology, biochemistry, and behavior2009
Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine.
Article in Pharmacology, biochemistry, and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Appetitive Pavlovian conditioning of the stimulus effects of nicotine enhances later nicotine self-administration.Journal of the experimental analysis of behavior · 2022Article
- Understanding the stimulus effects of nicotine and bupropion in a drug-drug discriminated goal-tracking task.Psychopharmacology · 2022Article
- β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue.Frontiers in behavioral neuroscience · 2022Article
- The effect of sazetidine-A and other nicotinic ligands on nicotine controlled goal-tracking in female and male rats.Neuropharmacology · 2017Article
- Nicotine-induced enhancement of Pavlovian alcohol-seeking behavior in rats.Psychopharmacology · 2017Article
- The effect of switching pharmacological intervention during extinction on nicotine-evoked conditioned responding in rats.Psychopharmacology · 2015Article
- Blockade of cholinergic transmission elicits somatic signs in nicotine-naïve adolescent rats.Frontiers in pharmacology · 2015Article
- Interoception and learning: import to understanding and treating diseases and psychopathologies.ACS chemical neuroscience · 2014Review
- Interoceptive conditioning in rats: effects of using a single training dose or a set of 5 different doses of nicotine.Pharmacology, biochemistry, and behavior · 2013Article
- Iptakalim attenuates self-administration and acquired goal-tracking behavior controlled by nicotine.Neuropharmacology · 2013Article
- Interoceptive conditioning with a nicotine stimulus is susceptible to reinforcer devaluation.Behavioral neuroscience · 2013Article
- α3β4 nicotinic acetylcholine receptors in the medial habenula modulate the mesolimbic dopaminergic response to acute nicotine in vivo.Neuropharmacology · 2012Article
- Pharmacologic characterization of a nicotine-discriminative stimulus in rhesus monkeys.The Journal of pharmacology and experimental therapeutics · 2012Article
- Disentangling the nature of the nicotine stimulus.Behavioural processes · 2012Review
- Conditioned response evoked by nicotine conditioned stimulus preferentially induces c-Fos expression in medial regions of caudate-putamen.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Selective nicotinic receptor antagonists: effects on attention and nicotine-induced attentional enhancement.Psychopharmacology · 2011Article
- An examination of NMDA receptor contribution to conditioned responding evoked by the conditional stimulus effects of nicotine.Psychopharmacology · 2011Article
- Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation.Journal of medicinal chemistry · 2010Article
- Transfer of the discriminative stimulus effects of Δ9-THC and nicotine from one operant response to another in rats.Psychopharmacology · 2010Article
- Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine.Neuropharmacology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Current smokers express the desire to quit. However, the majority find it difficult to remain abstinent. As such, research efforts continually seek to develop more effective treatment. One such area of research involves the interoceptive stimulus effects of nicotine as either a discriminative stimulus in an operant drug discrimination task, or more recently as a conditional stimulus (CS) in a discriminated goal-tracking task. The present work investigated the potential role nicotinic acetylcholine receptors play in the CS effects of nicotine (0.4mg/kg) using antagonists with differential selectivity for beta2*, alpha7*, alpha6beta2*, and alpha3beta4* receptors. Methyllycaconitine (MLA) had no effect on nicotine-evoked conditioned responding. Mecamylamine and dihydro-beta-erythroidine (DHbetaE) dose-dependently blocked responding evoked by the nicotine CS. In a time-course assessment of mecamylamine and DHbetaE, each blocked conditioned responding when given 5min before testing and still blocked conditioned responding when administered 200min before testing. Two novel bis-picolinium analogs (N, N'-(3, 3'-(dodecan-1,12-diyl)-bis-picolinium dibromide [bPiDDB], and N, N'-(decan-1,10-diyl)-bis-picolinium diiodide [bPiDI]) did not block nicotine-evoked conditioned responding. Finally, pretreatment with low dose combinations of mecamylamine, dextromethorphan, and/or bupropion was used to target alpha3beta4* receptors. No combination blocked conditioned responding evoked by the training dose of nicotine. However, a combination of mecamylamine and dextromethorphan partially blocked nicotine-evoked conditioned responding to a lower dose of nicotine (0.1mg/kg). These results indicate that beta2* and potentially alpha3beta4* nicotinic acetylcholine receptors play a role in the CS effects of nicotine and are potential targets for the development of nicotine cessation aids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.