ArticleBMC psychiatry2009
Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects.
Article in BMC psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Locus-Specific Genetic Associations at theAdvanced genetics (Hoboken, N.J.) · 2026Article
- Sex-specific cortical, hippocampal and thalamic whole genome transcriptome data from controls and a G72 schizophrenia mouse model.BMC research notes · 2024Article
- Genetic EffectsNeuropsychiatric disease and treatment · 2020Article
- Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank.Wellcome open research · 2017Article
- The effect of neurogranin on neural correlates of episodic memory encoding and retrieval.Schizophrenia bulletin · 2013Article
- The effects of a DTNBP1 gene variant on attention networks: an fMRI study.Behavioral and brain functions : BBF · 2010Article
- The DAOA/G30 locus and affective disorders: haplotype based association study in a polydiagnostic approach.BMC psychiatry · 2010Article
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Authors and funding
11 authors.
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Abstract
backgroundIn the last years, several susceptibility genes for psychiatric disorders have been identified, among others G72 (also named D-amino acid oxidase activator, DAOA). Typically, the high-risk variant of a vulnerability gene is associated with decreased cognitive functions already in healthy individuals. In a recent study however, a positive effect of the high-risk variant of G72 on verbal working memory was reported. In the present study, we therefore examined the relationship between G72 genotype status and a broad range of cognitive functions in 423 healthy individuals.
methodsThe G72 carrier status was assessed by the two single nucleotide polymorphisms (SNPs) M23 and M24. Subjects were divided into three risk groups (low, intermediate and high risk).
resultsG72 status influenced a number of cognitive functions, such as verbal working memory, attention, and, at a trend level, spatial working memory and executive functions. Interestingly, the high-risk allele carriers scored better than one or even both other groups.
conclusionOur data show that the putative high-risk haplotype (i.e. homozygote C/C-allele carriers in SNP M23 and homozygote T/T-allele carriers in SNP M24) is in healthy individuals not necessarily associated with worse performance in cognitive functions, but even with better performance in some domains. Further work is required to identify the mechanisms of G72 on brain functions.
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