ArticleTissue engineering. Part A2010
Angiogenesis in a microvascular construct for transplantation depends on the method of chamber circulation.
Article in Tissue engineering. Part A, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Adipose-derived microvascular fragments: Functional microtissue units driving vascular integration and multidimensional tissue regeneration.Regenerative therapy · 2026Review
- Decellularized Cell-Secreted Extracellular Matrices as Biomaterials for Tissue Engineering.Small science · 2025Review
- Adaptation process of decellularized vascular grafts as hemodialysis accessRegenerative biomaterials · 2024Article
- Generation of Connective Tissue-Free Microvascular Fragment Isolates from Subcutaneous Fat Tissue of Obese Mice.Tissue engineering and regenerative medicine · 2023Article
- Vascularized Tissue Organoids.Bioengineering (Basel, Switzerland) · 2023Review
- Methods for vascularization and perfusion of tissue organoids.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- Scaffold Architecture and Matrix Strain Modulate Mesenchymal Cell and Microvascular Growth and Development in a Time Dependent Manner.Cellular and molecular bioengineering · 2020Article
- 3D bioprinting and its potential impact on cardiac failure treatment: An industry perspective.APL bioengineering · 2020Article
- Type I Diabetes Delays Perfusion and Engraftment of 3D Constructs by Impinging on Angiogenesis; Which can be Rescued by Hepatocyte Growth Factor Supplementation.Cellular and molecular bioengineering · 2019Article
- Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation.Biomaterials · 2018Article
- Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics.Scientific reports · 2017Article
- Article
- Inosculation and perfusion of pre-vascularized tissue patches containing aligned human microvessels after myocardial infarction.Biomaterials · 2016Article
- Engineered microvessels with strong alignment and high lumen density via cell-induced fibrin gel compaction and interstitial flow.Tissue engineering. Part A · 2014Article
- Extracellular matrix density regulates the rate of neovessel growth and branching in sprouting angiogenesis.PloS one · 2014Article
- Manipulating the microvasculature and its microenvironment.Critical reviews in biomedical engineering · 2013Review
- Generation of a functional liver tissue mimic using adipose stromal vascular fraction cell-derived vasculatures.Scientific reports · 2013Article
- Determinants of microvascular network topologies in implanted neovasculatures.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Direct-write bioprinting three-dimensional biohybrid systems for future regenerative therapies.Journal of biomedical materials research. Part B, Applied biomaterials · 2011Review
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effective tissue prevascularization depends on new vessel growth and subsequent progression of neovessels into a stable microcirculation. Isolated microvessel fragments in a collagen-based microvascular construct (MVC) spontaneously undergo angiogenesis in static conditions in vitro but form a new microcirculation only when implanted in vivo. We have designed a bioreactor, the dynamic in vitro perfusion (DIP) chamber, to culture MVCs in vitro with perfusion. By altering bioreactor circulation, microvessel fragments in the DIP chamber either maintained stable, nonsprouting, patent vessel morphologies or sprouted endothelial neovessels that extended out into the surrounding collagen matrix (i.e., angiogenesis), yielding networks of neovessels within the MVC. Neovessels formed in regions of the construct predicted by simulation models to have the steepest gradients in oxygen levels and expressed hypoxia inducible factor-1alpha. By altering circulation conditions in the DIP chamber, we can control, possibly by modulating hypoxic stress, prevascularizing activity in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.