ArticleWorld journal of gastroenterology2009
COX-2 polymorphisms -765G-->C and -1195A-->G and colorectal cancer risk.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- COX-2 gene rs689466 polymorphism is associated with increased risk of colorectal cancer among Caucasians: a meta-analysis.World journal of surgical oncology · 2020Pooled it
- Association between COX-2 -1195G>A polymorphism and gastrointestinal cancer risk: A meta-analysis.World journal of gastroenterology · 2017Pooled it
- Meta-analysis of the association between COX-2 polymorphisms and risk of colorectal cancer based on case-control studies.PloS one · 2014Pooled it
- Cyclooxygenase-2 polymorphisms were associated with the risk of gastric cancer: evidence from a meta-analysis based on case-control studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Cyclooxygenase-2 polymorphisms and susceptibility to colorectal cancer: a meta-analysis.Yonsei medical journal · 2013Pooled it
- Pooled it
- Trial
- Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review.Frontiers in oncology · 2022Review
- Association of COX2 -765G>C promoter polymorphism and coronary artery disease in Korean population.Genes & genomics · 2019Article
- Cyclooxygenase-2 gene polymorphisms and susceptibility to colorectal cancer in a Brazilian population.Journal of gastrointestinal oncology · 2017Article
- Cyclooxygenase-2 -1195G>A (rs689466) polymorphism and cancer susceptibility: an updated meta-analysis involving 50,672 subjects.International journal of clinical and experimental medicine · 2015Article
- Study of the polymorphisms of cyclooxygenase-2 (-765G>C) and 5-lipoxygenase (1708G>A) in patients with colorectal cancer.Oncology letters · 2014Article
- Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer.Familial cancer · 2013Article
- Association of the -14C/G MET and the -765G/C COX-2 gene polymorphisms with the risk of chronic rhinosinusitis with nasal polyps in a Polish population.DNA and cell biology · 2012Article
- Cyclooxygenase-2 -765 G/C polymorphisms and susceptibility to hepatitis B-related liver cancer in Han Chinese population.Molecular biology reports · 2012Article
- Cyclooxygenase-2 gene and lung carcinoma risk.Medical oncology (Northwood, London, England) · 2011Article
- Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors.The pharmacogenomics journal · 2011Article
- Role of cyclooxygenase-2 gene polymorphisms in pancreatic carcinogenesis.World journal of gastroenterology · 2011Article
- Cyclooxygenase-2 gene and epithelial ovarian carcinoma risk.Molecular biology reports · 2011Article
- The functional -765G→C polymorphism of the COX-2 gene may reduce the risk of developing crohn's disease.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the possible modulating effect of the COX-2 polymorphisms, -765G-->C and -1195A-->G, on the risk of colorectal cancer (CRC) in a Dutch population.
methodsThis case-control study includes 326 patients with CRC and 369 age- and gender-matched controls. Genotypes of the COX-2 polymorphisms -765G-->C and -1195A-->G were determined by polymerase chain reaction-based restriction fragment length polymorphism. COX-2 genotypes and haplotypes were analyzed and odds ratios with 95% confidence intervals were estimated by logistic regression.
resultsThe -765GG genotype was associated with an increased risk of developing CRC (OR, 1.45; 95% CI, 1.03-2.04). No significant difference was observed in the genotype distribution of the -1195A-->G polymorphism between patients and controls. The GG/AC haplotype was present significantly less often in patients than in controls (OR 0.44; 95% CI, 0.22-0.85). When the AC, AG and GG haplotypes were investigated separately, the AC haplotype showed a tendency to be less frequent in patients than in controls (OR((AG/AC)) 0.78; 95% CI, 0.57-1.06).
conclusionThe -765GG genotype is associated with an increased risk of developing CRC and the GG/AC haplotype seems to protect against CRC. These findings suggest a modulating role for the COX-2 polymorphisms -765G-->C and -1195A-->G in the development of CRC in a Dutch population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.