ArticleWorld journal of gastroenterology2009
Protein interaction network related to Helicobacter pylori infection response.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- Interrelation between Stress Management and Secretion Systems ofPathogens (Basel, Switzerland) · 2022Article
- Aqueous extract fromHeliyon · 2019Article
- The Protein-Protein Interaction Network ofFrontiers in physiology · 2019Article
- Inhibition of EGF expression and NF-κB activity by treatment with quercetin leads to suppression of angiogenesis in nasopharyngeal carcinoma.Saudi journal of biological sciences · 2018Article
- Reconstruction and Application of Protein-Protein Interaction Network.International journal of molecular sciences · 2016Review
- Computational analysis of protein interaction networks for infectious diseases.Briefings in bioinformatics · 2016Review
- Gastric cancer development after the successful eradication of Helicobacter pylori.World journal of gastrointestinal oncology · 2016Review
- Identification of putative drug targets for human sperm-egg interaction defect using protein network approach.BMC systems biology · 2015Article
- Structural modifications of Helicobacter pylori lipopolysaccharide: an idea for how to live in peace.World journal of gastroenterology · 2014Review
- The protein-protein interaction network of eyestalk, Y-organ and hepatopancreas in Chinese mitten crab Eriocheir sinensis.BMC systems biology · 2014Article
- Helicobacter pylori infection: host immune response, implications on gene expression and microRNAs.World journal of gastroenterology · 2014Review
- Epigenetic modifications induced by Helicobacter pylori infection through a direct microbe-gastric epithelial cells cross-talk.Medical microbiology and immunology · 2013Review
- Construction and analysis of the protein-protein interaction network related to essential hypertension.BMC systems biology · 2013Article
- Time-series gene expression profiles in AGS cells stimulated with Helicobacter pylori.World journal of gastroenterology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo understand the complex reaction of gastric inflammation induced by Helicobacter pylori (H pylori) in a systematic manner using a protein interaction network.
methodsThe expression of genes significantly changed on microarray during H pylori infection was scanned from the web literary database and translated into proteins. A network of protein interactions was constructed by searching the primary interactions of selected proteins. The constructed network was mathematically analyzed and its biological function was examined. In addition, the nodes on the network were checked to determine if they had any further functional importance or relation to other proteins by extending them.
resultsThe scale-free network showing the relationship between inflammation and carcinogenesis was constructed. Mathematical analysis showed hub and bottleneck proteins, and these proteins were mostly related to immune response. The network contained pathways and proteins related to H pylori infection, such as the JAK-STAT pathway triggered by interleukins. Activation of nuclear factor (NF)-kappaB, TLR4, and other proteins known to function as core proteins of immune response were also found. These immune-related proteins interacted on the network with pathways and proteins related to the cell cycle, cell maintenance and proliferation, and transcription regulators such as BRCA1, FOS, REL, and zinc finger proteins. The extension of nodes showed interactions of the immune proteins with cancer-related proteins. One extended network, the core network, a summarized form of the extended network, and cell pathway model were constructed.
conclusionImmune-related proteins activated by H pylori infection interact with proto-oncogene proteins. The hub and bottleneck proteins are potential drug targets for gastric inflammation and cancer.
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