ArticleWorld journal of gastroenterology2009
Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells.
Article in World journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Heme Oxygenase-1 Regulates Zearalenone-Induced Oxidative Stress and Apoptosis in Sheep Follicular Granulosa Cells.International journal of molecular sciences · 2024Article
- HMOX1 Promotes Ferroptosis in Mammary Epithelial Cells via FTH1 and Is Involved in the Development of Clinical Mastitis in Dairy Cows.Antioxidants (Basel, Switzerland) · 2022Article
- Therapeutic Potential of Inducible Endogenous Cytoprotective Heme Oxygenase-1 in Mitigating SARS-CoV-2 Infection and Associated Inflammation.Antioxidants (Basel, Switzerland) · 2022Article
- Hemin activation abrogates Mycoplasma hyorhinis replication in chronically infected prostate cancer cells via heme oxygenase-1 induction.FEBS open bio · 2021Article
- Relationship between Hepatitis C Virus Infection and Iron Overload.Chinese medical journal · 2017Review
- Nrf2-dependent induction of innate host defense via heme oxygenase-1 inhibits Zika virus replication.Virology · 2017Article
- Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis.Oncotarget · 2017Review
- Defective iron homeostasis in human immunodeficiency virus type-1 latency.Current trends in immunology · 2016Article
- Therapeutic potential of the heme oxygenase-1 inducer hemin against Ebola virus infection.Current trends in immunology · 2016Article
- Non-coding RNAs and heme oxygenase-1 in vaccinia virus infection.Biochemical and biophysical research communications · 2014Article
- Role of Nrf2 in chronic liver disease.World journal of gastroenterology · 2014Review
- Hepatic HMOX1 expression positively correlates with Bach-1 and miR-122 in patients with HCV mono and HIV/HCV coinfection.PloS one · 2014Article
- Heme oxygenase-1 induction alters chemokine regulation and ameliorates human immunodeficiency virus-type-1 infection in lipopolysaccharide-stimulated macrophages.Biochemical and biophysical research communications · 2013Article
- HCV and oxidative stress in the liver.Viruses · 2013Review
- Bilirubin: An Endogenous Molecule with Antiviral Activity in vitro.Frontiers in pharmacology · 2012Article
- Heme and HO-1 Inhibition of HCV, HBV, and HIV.Frontiers in pharmacology · 2012Article
- Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells.The Journal of biological chemistry · 2011Article
- NRF2 Oxidative Stress Induced by Heavy Metals is Cell Type Dependent.Current chemical genomics · 2011Article
- The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes.Biochimica et biophysica actaArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
aimTo investigate effects of iron on oxidative stress, heme oxygenase-1 (HMOX1) and hepatitis C viral (HCV) expression in human hepatoma cells stably expressing HCV proteins.
methodsEffects of iron on oxidative stress, HMOX1, and HCV expression were assessed in CON1 cells. Measurements included mRNA by quantitative reverse transcription-polymerase chain reaction, and protein levels by Western blots.
resultsIron, in the form of ferric nitrilotriacetate, increased oxidative stress and up-regulated HMOX1 gene expression. Iron did not affect mRNA or protein levels of Bach1, a repressor of HMOX1. Silencing the up-regulation of HMOX1 nuclear factor-erythroid 2-related factor 2 (Nrf2) by Nrf2-siRNA decreased FeNTA-mediated up-regulation of HMOX1 mRNA levels. These iron effects were completely blocked by deferoxamine (DFO). Iron also significantly decreased levels of HCV core mRNA and protein by 80%-90%, nonstructural 5A mRNA by 90% and protein by about 50% in the Con1 full length HCV replicon cells, whereas DFO increased them.
conclusionExcess iron up-regulates HMOX1 and down-regulates HCV gene expression in hepatoma cells. This probably mitigates liver injury caused by combined iron overload and HCV infection.
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Registered trials
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