Evidence map›Paper›PMID 19777535›Full record

Trial reportPsycho-oncology2010

The association of depression and anxiety with health-related quality of life in cancer patients with depression and/or pain.

Linda F Brown, Kurt Kroenke, Dale E Theobald, Jingwei Wu, Wanzhu Tu

2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psycho-oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 117 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00313573 phase3unknown statusnot on this map

TeleCare Management of Pain and Depression in Cancer

TypeinterventionalSponsorIndiana UniversityRan2006Enrolled480ConditionsDepression, Pain, Unspecified Adult Solid Tumor, Protocol SpecificArmsmanagement of therapy complications, pain therapy, psychosocial assessment and care, quality-of-life assessment
NCT03649737 nacompletednot on this mapstarted 2018, after this paper: background citation

Pilot Study of a Progressive Exercise Program Among Lung Cancer Patient-Partner Dyads

TypeinterventionalSponsorOHSU Knight Cancer InstituteRan2018 to 2019Enrolled46ConditionsLung Cancer, Depression, Physical Activity, Quality of LifeArmsExercise Intervention, Survey Administration, Quality-of-Life Assessment
3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  4. Effects of Internet-based psycho-educational interventions on mental health and quality of life among cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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  10. Collaborative care for depression and anxiety problems.The Cochrane database of systematic reviews · 2012
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Linda F BrownDepartment of Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA. lfbrown@iupui.edu
Kurt Kroenke
Dale E Theobald
Jingwei Wu
Wanzhu Tu

Funding

Training in Research for Behavioral Oncology and Cancer Control ProgramR25CA117865 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CHAMPION, VICTORIA LEE · 2006 to 2015
$4.1M
TeleCare Management of Pain and Depression in CancerR01CA115369 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KROENKE, KURT · 2005 to 2009
$2.1M
NCI NIH HHS R01 CA115369NCI NIH HHS R01CA-115369NCI NIH HHS R25 CA117865NCI NIH HHS R25 CA-117865-01A11
6 · The paper itself

Abstract

objectivesDepression is known to be a major problem in cancer patients, and evidence is emerging about the importance of anxiety. Because the disorders are highly comorbid, we examined the relationship of anxiety and depression with health-related quality of life (HRQL) in cancer patients.

methodsSample included 405 adult oncology patients participating in a randomized controlled trial of telecare management for pain and depression. This secondary cross-sectional analysis of baseline data examined independent and additive effects of anxiety and depression on HRQL, disability, and somatic symptom severity.

resultsIn 397 patients who screened positive for either pain or depression or both, 135 had comorbid anxiety and depression, 174 had depression but not anxiety, and 88 had neither. Differences existed across all nonphysical HRQL domains and were more pronounced incrementally across the three groups in the expected direction. In GLM modeling, anxiety and depression were each associated with all the domains when modeled separately (p<0.0001). When modeled together, anxiety and depression had independent and additive effects on the mental health domains of HRQL and on somatic symptom burden. In other domains (vitality, perceived disability, overall quality of life, and general health perceptions), only depression had an effect.

conclusionAnxiety and depression have strong and independent associations with mental health domains and somatic symptom burden in cancer patients. However, depression has a more pervasive association with multiple other domains of HRQL. Paying attention to both anxiety and depression may be particularly important when addressing mental health needs and somatic symptom distress.

Indexed as

Remote ConsultationAdultAgedAnxiety DisordersCancer Care FacilitiesCost of IllnessCross-Sectional StudiesDepressive DisorderDisability EvaluationFemaleHumansMaleMass ScreeningMiddle AgedNeoplasmsPain

Identifiers

PMID19777535
PMCPMC2888919

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.