ReviewReviews in endocrine & metabolic disorders2009
Expression of clock genes in the suprachiasmatic nucleus: effect of environmental lighting conditions.
Review in Reviews in endocrine & metabolic disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed.
- Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy.Frontiers in endocrinology · 2025Review
- The impact of seasonal variations on IVF pregnancy outcomes: a retrospective cohort study in Jinan, China.Frontiers in medicine · 2025Article
- SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Constant Light Dysregulates Cochlear Circadian Clock and Exacerbates Noise-Induced Hearing Loss.International journal of molecular sciences · 2020Article
- Circadian and photic modulation of daily rhythms in diurnal mammals.The European journal of neuroscience · 2020Review
- Insights into the Role of Circadian Rhythms in Bone Metabolism: A Promising Intervention Target?BioMed research international · 2018Review
- The dynamics of GABA signaling: Revelations from the circadian pacemaker in the suprachiasmatic nucleus.Frontiers in neuroendocrinology · 2017Review
- Acute inhibition of casein kinase 1δ/ε rapidly delays peripheral clock gene rhythms.Molecular and cellular biochemistry · 2015Article
- Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators.Psychoneuroendocrinology · 2014Article
- Dynamic interactions mediated by nonredundant signaling mechanisms couple circadian clock neurons.Neuron · 2013Article
- Daily variations in plasma melatonin and melatonin receptor (MT1), PER1 and CRY1 expression in suprachiasmatic nuclei of tropical squirrel, Funambulus pennanti.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
- Intrinsic regulation of spatiotemporal organization within the suprachiasmatic nucleus.PloS one · 2011Article
- Impaired sodium levels in the suprachiasmatic nucleus are associated with the formation of cardiovascular deficiency in sleep-deprived rats.Journal of anatomy · 2010Article
- Physiological responses of the circadian clock to acute light exposure at night.Reviews in endocrine & metabolic disorders · 2009Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The suprachiasmatic nucleus (SCN) is the anatomical substrate for the principal circadian clock coordinating daily rhythms in a vast array of behavioral and physiological responses. Individual SCN neurons are cellular oscillators and are organized into a multi-oscillator network following unique spatiotemporal patterns. The rhythms generated in the SCN are generally entrained to the environmental light dark cycle, which is the most salient cue influencing the network organization of the SCN. The neural network in the SCN is a heterogeneous structure, containing two major compartments identified by applying physiological and functional criteria, namely the retinorecipient core region and the highly rhythmic shell region. Changes in the environmental lighting condition are first detected and processed by the core region, and then conveyed to the rest of the SCN, leading to adaptive responses of the entire network. This review will focus on the studies that explore the responses of the SCN network by examining the expression of clock genes, under various lighting paradigms, such as acute light exposure, lighting schedules or exposure to different light durations. The results will be discussed under the framework of functionally distinct SCN sub regions and oscillator groups. The evidence presented here suggests that the environmental lighting conditions alter the spatiotemporal organization of the cellular oscillators within the SCN, which consequently affect the overt rhythms in behavior and physiology. Thus, information on how the SCN network elements respond to environmental cues is key to understanding the human health problems that stem from circadian rhythm disruption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.