SynthesisDigestive diseases and sciences2010
Polymorphism of IL-8 in 251 allele and gastric cancer susceptibility: a meta-analysis.
Synthesis in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 10 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 10 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis.BioMed research international · 2018Pooled it
- Association of HLA-DRB1 Gene Polymorphism with Risk of Asthma: A Meta-Analysis.Medical science monitor basic research · 2016Pooled it
- Meta-Analysis of the Relationship between XRCC1-Arg399Gln and Arg280His Polymorphisms and the Risk of Prostate Cancer.Scientific reports · 2015Pooled it
- Pooled it
- Meta-analysis on the relationship between HLA-DRBl gene polymorphism and cervical cancer in Chinese population.PloS one · 2014Pooled it
- Interleukin-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.Rheumatology international · 2012Pooled it
- -251 T/A polymorphism of the interleukin-8 gene and cancer risk: a HuGE review and meta-analysis based on 42 case-control studies.Molecular biology reports · 2012Pooled it
- A meta-analysis of interleukin-8 -251 promoter polymorphism associated with gastric cancer risk.PloS one · 2012Pooled it
- The association between interleukin-10-592 polymorphism and gastric cancer risk: a meta-analysis.Medical oncology (Northwood, London, England) · 2011Pooled it
- Pooled it
- Identification of immune-related mechanisms of cetuximab induced skin toxicity in colorectal cancer patients.PloS one · 2022Article
- State of Art of Cancer Pharmacogenomics in Latin American Populations.International journal of molecular sciences · 2017Review
- Article
- Unique Clinicopathology of Proximal Gastric Carcinoma: A Critical Review.Gastrointestinal tumors · 2014Review
- CXC chemokines and chemokine receptors in gastric cancer: from basic findings towards therapeutic targeting.World journal of gastroenterology · 2014Review
- Genotyping of IL-8-251 T > A yields prognostic information in patients with gastric carcinoma.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2013Article
- Positive association between Interleukin-8 -251A > T polymorphism and susceptibility to gastric carcinogenesis: a meta-analysis.Cancer cell international · 2013Article
- Chemokines, chemokine receptors and the gastrointestinal system.World journal of gastroenterology · 2013Review
- Interleukin-8 is associated with adhesion, migration and invasion in human gastric cancer SCG-7901 cells.Medical oncology (Northwood, London, England) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship of gastric cancer to the presence of interleukin-8 (IL-8) 251 T/A has been reported with conflicting results.
aimTo further explore the association of IL-8 251 allele polymorphism with gastric cancer susceptibility.
methodsWe performed an extensive search of relevant studies and carried out a meta-analysis, including ten studies with 2,195 gastric cancer cases and 3,505 controls, to obtain a more precise estimate.
resultsThe combined results based on all studies showed that the IL-8 251 allele AA genotype was a risk factor for gastric cancer [AA versus TT: odds ratio (OR) = 1.363, 95% confidence interval (CI): 1.199-1.527]. In subgroup analysis, a clear effect of AA in IL-8 251 allele was shown in Asians (AA versus TT: OR = 1.593, 95% CI: 1.013-2.173) but not in Caucasians or Mexicans. When stratified by Lauren classification, we found that the IL-8 251 allele TA and AA polymorphism was significantly associated with the diffuse type of gastric cancer (TA versus TT: OR = 1.448, 95% CI: 1.177-1.720; AA versus TT: OR = 1.586, 95% CI: 1.128-2.044). The IL-8 251 AA genotype was found to be a risk factor for cardiac gastric cancer (AA versus TT: OR = 1.840, 95% CI: 1.112-2.568) but not for noncardiac gastric cancer.
conclusionsThis meta-analysis suggested that IL-8 251 allele A>T polymorphism might be a risk factor for gastric cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.