ArticleFunctional & integrative genomics2010
Enhanced mitochondrial complex gene function and reduced liver size may mediate improved feed efficiency of beef cattle during compensatory growth.
Article in Functional & integrative genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 85 citations in OpenAlex.
- Integrated multi-omics of the ruminal microbiome and host metabolome reveals compensatory growth in response to dietary energy restriction and re-alimentation in growing beef bulls.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Sequence-based genome-wide association study reveals genetic and metabolic mechanisms underlying feed efficiency-related traits in beef cattle.Journal of animal science and biotechnology · 2026Article
- Dietary protein re-alimentation following restriction improves protein deposition via changing amino acid metabolism and transcriptional profiling of muscle tissue in growing beef bulls.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Transcriptome Analysis of Compensatory Growth and Meat Quality Alteration after Varied Restricted Feeding Conditions in Beef Cattle.International journal of molecular sciences · 2024Article
- Identification of copy number variation in Tibetan sheep using whole genome resequencing reveals evidence of genomic selection.BMC genomics · 2023Article
- Transcriptome Profiling of the Liver in Nellore Cattle Phenotypically Divergent for RFI in Two Genetic Groups.Animals : an open access journal from MDPI · 2023Article
- Analysis of runs of homozygosity of cattle living in different climate zones.Journal of animal science · 2023Article
- Starvation causes changes in the intestinal transcriptome and microbiome that are reversed upon refeeding.BMC genomics · 2022Article
- Transcriptome analysis reveals the potential roles of long non-coding RNAs in feed efficiency of chicken.Scientific reports · 2022Article
- Transcriptome profiles of the skeletal muscle of mature cows during feed restriction and realimentation.BMC research notes · 2021Article
- An examination of skeletal muscle and hepatic tissue transcriptomes from beef cattle divergent for residual feed intake.Scientific reports · 2021Article
- Signatures of selection reveal candidate genes involved in economic traits and cold acclimation in five Swedish cattle breeds.Genetics, selection, evolution : GSE · 2020Article
- Genome Regulation and Gene Interaction Networks Inferred From Muscle Transcriptome Underlying Feed Efficiency in Pigs.Frontiers in genetics · 2020Article
- Article
- Microarray and metabolome analysis of hepatic response to fasting and subsequent refeeding in zebrafish (Danio rerio).BMC genomics · 2019Article
- Effect of divergence in residual feed intake on expression of lipid metabolism-related genes in the liver of meat-type ducks1.Journal of animal science · 2019Article
- Genetic parameters and genome-wide association study regarding feed efficiency and slaughter traits in Charolais cows.Journal of animal science · 2019Article
- Integrating genome-wide co-association and gene expression to identify putative regulators and predictors of feed efficiency in pigs.Genetics, selection, evolution : GSE · 2019Article
- Gene co-expression networks contributing to the expression of compensatory growth in metabolically active tissues in cattle.Scientific reports · 2019Article
- Liver proteomics unravel the metabolic pathways related to Feed Efficiency in beef cattle.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growing ruminants under extended dietary restriction exhibit compensatory growth upon ad libitum feeding, which is associated with increased feed efficiency, lower basal energy requirements, and changes in circulating concentrations of metabolic hormones. To identify mechanisms contributing to these physiological changes, 8-month-old steers were fed either ad libitum (control; n = 6) or 60-70% of intake of control animals (feed-restricted; n = 6) for a period of 12 weeks. All steers were fed ad libitum for the remaining 8 weeks of experimentation (realimentation). Liver was biopsied at days -14, +1, and +14 relative to realimentation for gene expression analysis by microarray hybridization. During early realimentation, feed-restricted steers exhibited greater rates of gain and feed efficiency than controls and an increase in expression of genes functioning in cellular metabolism, cholesterol biosynthesis, oxidative phosphorylation, glycolysis, and gluconeogenesis. Gene expression changes during feed restriction were similar to those reported in mice, indicating similar effects of caloric restriction across species. Based on expression of genes involved in cell division and growth and upregulation of genes encoding mitochondrial complex proteins in early realimentation, it was concluded that reduced hepatic size and increased mitochondrial function may contribute to improved feed efficiency observed during compensatory growth.
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