ArticlePloS one2009
A computational study on the role of gap junctions and rod Ih conductance in the enhancement of the dynamic range of the retina.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- Systematic generation of biophysically detailed models with generalization capability for non-spiking neurons.PloS one · 2022Article
- Modeling ON Cone Bipolar Cells for Electrical Stimulation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
- A Computational Model Simulates Light-Evoked Responses in the Retinal Cone Pathway.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
- Model-based comparison of current flow in rod bipolar cells of healthy and early-stage degenerated retina.Experimental eye research · 2021Article
- Increasing Electrical Stimulation Efficacy in Degenerated Retina: Stimulus Waveform Design in a Multiscale Computational Model.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2018Article
- Article
- Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons.Scientific reports · 2017Article
- Coexistence of critical sensitivity and subcritical specificity can yield optimal population coding.Journal of the Royal Society, Interface · 2017Article
- Modulation of neuronal dynamic range using two different adaptation mechanisms.Neural regeneration research · 2017Article
- On the computation of a retina resistivity profile for applications in multi-scale modeling of electrical stimulation and absorption.Physics in medicine and biology · 2016Article
- Computational Modeling of Single Neuron Extracellular Electric Potentials and Network Local Field Potentials using LFPsim.Frontiers in computational neuroscience · 2016Article
- Rod electrical coupling is controlled by a circadian clock and dopamine in mouse retina.The Journal of physiology · 2015Article
- Undersampled critical branching processes on small-world and random networks fail to reproduce the statistics of spike avalanches.PloS one · 2014Article
- Single-neuron criticality optimizes analog dendritic computation.Scientific reports · 2013Article
- Developmental and functional expression of miRNA-stability related genes in the nervous system.PloS one · 2013Article
- Dynamic range of vertebrate retina ganglion cells: importance of active dendrites and coupling by electrical synapses.PloS one · 2012Article
- Article
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3 authors.
Funding
Abstract
Recent works suggest that one of the roles of gap junctions in sensory systems is to enhance their dynamic range by avoiding early saturation in the first processing stages. In this work, we use a minimal conductance-based model of the ON rod pathways in the vertebrate retina to study the effects of electrical synaptic coupling via gap junctions among rods and among AII amacrine cells on the dynamic range of the retina. The model is also used to study the effects of the maximum conductance of rod hyperpolarization activated current I(h) on the dynamic range of the retina, allowing a study of the interrelations between this intrinsic membrane parameter with those two retina connectivity characteristics. Our results show that for realistic values of I(h) conductance the dynamic range is enhanced by rod-rod coupling, and that AII-AII coupling is less relevant to dynamic range amplification in comparison with receptor coupling. Furthermore, a plot of the retina output response versus input intensity for the optimal parameter configuration is well fitted by a power law with exponent approximately 0.5. The results are consistent with predictions of more theoretical works and suggest that the earliest expression of gap junctions along the rod pathways, together with appropriate values of rod I(h) conductance, has the highest impact on vertebrate retina dynamic range enhancement.
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