ArticlePloS one2009
FGF4 independent derivation of trophoblast stem cells from the common vole.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- Leveraging chorionic villus biopsies for the derivation of patient-specific trophoblast stem cells.Communications biology · 2025Article
- Conserved and divergent features of trophoblast stem cells.Journal of molecular endocrinology · 2024Review
- Hemochorial placentation: development, function, and adaptations.Biology of reproduction · 2018Review
- Article
- Mapping of Replication Origins in the X Inactivation Center of Vole Microtus levis Reveals Extended Replication Initiation Zone.PloS one · 2015Article
- Dynamics of the two heterochromatin types during imprinted X chromosome inactivation in vole Microtus levis.PloS one · 2014Article
- Structure functional analysis of the vole Nanog 5' regulatory region.Doklady. Biochemistry and biophysics · 2013Article
- Generation of colonies of induced trophoblast cells during standard reprogramming of porcine fibroblasts to induced pluripotent stem cells.Biology of reproduction · 2011Article
- Trophoblast stem cells.Biology of reproduction · 2011Review
- FGF4-dependent stem cells derived from rat blastocysts differentiate along the trophoblast lineage.Developmental biology · 2011Article
- Article
- Article
- Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation.BMC developmental biology · 2010Article
- Article
- Replication origin activity in vole X chromosome inactivation center in different cell types.Doklady. Biochemistry and biophysicsArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
The derivation of stable multipotent trophoblast stem (TS) cell lines from preimplantation, and early postimplantation mouse embryos has been reported previously. FGF4, and its receptor FGFR2, have been identified as embryonic signaling factors responsible for the maintenance of the undifferentiated state of multipotent TS cells. Here we report the derivation of stable TS-like cell lines from the vole M. rossiaemeridionalis, in the absence of FGF4 and heparin. Vole TS-like cells are similar to murine TS cells with respect to their morphology, transcription factor gene expression and differentiation in vitro into derivatives of the trophectoderm lineage, and with respect to their ability to invade and erode host tissues, forming haemorrhagic tumours after subcutaneous injection into nude mice. Moreover, vole TS-like cells carry an inactive paternal X chromosome, indicating that they have undergone imprinted X inactivation, which is characteristic of the trophoblast lineage. Our results indicate that an alternative signaling pathway may be responsible for the establishment and stable proliferation of vole TS-like cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.