Evidence map›Paper›PMID 19776780›Full record

ReviewNature reviews. Nephrology2009

Renal transplantation in patients with HIV.

Lynda A Frassetto, Clara Tan-Tam, Peter G Stock

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Nephrology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00074386 (Solid Organ Transplantation in HIV), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00074386 completednot on this map

Solid Organ Transplantation in HIV: Multi-Site Study

TypeobservationalSponsorUniversity of California, San FranciscoRan2003 to 2013Enrolled275ConditionsHIV Infections, Kidney Disease, Liver Disease
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 49 citations in OpenAlex.

  1. Health-related quality of life and associated factors in HIV-positive transplant candidates and recipients from a HIV-positive donor.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Article
  2. Article
  3. Review
  4. Common viral infections in kidney transplant recipients.Kidney research and clinical practice · 2018
    Review
  5. Review
  6. Induction Immunosuppression and Clinical Outcomes in Kidney Transplant Recipients Infected With Human Immunodeficiency Virus.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016
    Article
  7. HIV and liver transplantation: The British Columbia experience, 2004 to 2013.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2014
    Article
  8. Observational
  9. Review
  10. Article
  11. Viral infection in renal transplant recipients.TheScientificWorldJournal · 2012
    Review
  12. Nephrotoxicity of HAART.AIDS research and treatment · 2011
    Article
  13. Renal Transplantation in HIV-Positive Recipients.Current infectious disease reports · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lynda A FrassettoDepartment of Medicine and Clinical Research Center, University of California, San Francisco, CA 94143, USA. frassett@gcrc.ucsf.edu
Clara Tan-Tam
Peter G Stock
University of California, San Francisco · US

Funding

ZD1839 FOR MALIGNANT ASTROCYTOMA OR GLIOBLASTOMA AND MENINGIOMAM01RR000079 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$26.0M
Solid Organ Transplantation in HIV: Multi-Site StudyU01AI052748 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STOCK, PETER G · 2003 to 2010
$25.9M
NCRR NIH HHS M01 RR000079NIAID NIH HHS AI052748NIAID NIH HHS U01 AI052748
6 · The paper itself

Abstract

HIV infection has been a major global health problem for almost three decades. With the introduction of highly active antiretroviral therapy in 1996, and the advent of effective prophylaxis and management of opportunistic infections, AIDS mortality has decreased markedly. In developed countries, this once fatal infection is now being treated as a chronic condition. As a result, rates of morbidity and mortality from other medical conditions leading to end-stage liver, kidney and heart disease are steadily increasing in individuals with HIV. Presence of HIV infection used to be viewed as a contraindication to transplantation for multiple reasons: concerns for exacerbation of an already immunocompromised state by administration of additional immunosuppressants; the use of a limited supply of donor organs with unknown long-term outcomes; and, the risk of viral transmission to the surgical and medical staff. This Review examines open questions on kidney transplantation in patients infected with HIV-1 and clinical strategies that have resulted in good outcomes. It also describes the clinical concerns associated with the treatment of renal transplant recipients with HIV.

Indexed as

Kidney TransplantationDrug InteractionsHIV InfectionsHumansKidney DiseasesPatient SelectionTreatment Outcome

Identifiers

PMID19776780
PMCPMC2925992
OpenAlexW1983283176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.