Evidence map›Paper›PMID 19776745›Full record

ReviewNature reviews. Cancer2009

p53 ancestry: gazing through an evolutionary lens.

Wan-Jin Lu, James F Amatruda, John M Abrams

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. On the Origin of Biomolecular Networks.Frontiers in genetics · 2019
    Pooled it
  2. Article
  3. Neuronal IL-17 controlsProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Evolutionary determinants of curability in cancer.Nature ecology & evolution · 2023
    Review
  5. Convergent TP53 loss and evolvability in cancer.BMC ecology and evolution · 2023
    Review
  6. NAR cancer · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Structural diversity of p63 and p73 isoforms.Cell death and differentiation · 2022
    Review
  12. RAD51: Beyond the break.Seminars in cell & developmental biology · 2021
    Review
  13. Unpicking the Roles of DNA Damage Protein Kinases in Trypanosomatids.Frontiers in cell and developmental biology · 2021
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wan-Jin LuWan-Jin Lu and John M. Abrams are at the Department of Cell Biology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390, USA.
James F Amatruda
John M Abrams

Funding

Molecular and Genetic Control of Programmed Cell DeathR56GM072124 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI ABRAMS, JOHN M · 2008 to 2008
$353k
NIGMS NIH HHS R56 GM072124
6 · The paper itself

Abstract

Evolutionary patterns indicate that primordial p53 genes predated the appearance of cancer. Therefore, wild-type tumour suppressive functions and mutant oncogenic functions that give celebrity status to this gene family were probably co-opted from unrelated primordial activities. Is it possible to deduce what these early functions might have been? And might this knowledge provide a platform for therapeutic opportunities?

Indexed as

Evolution, MolecularAnimalsGenes, p53HumansTumor Suppressor Protein p53Tumor Suppressor Protein p53

Identifiers

PMID19776745

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.