Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2010
Aggression, suicidality, and intermittent explosive disorder: serotonergic correlates in personality disorder and healthy control subjects.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05895513 (Effect of Pimavanserin on Aggression and Social Cognition.), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Pimavanserin on Aggression and Social Cognition.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Revisiting the serotonin-aggression relation in humans: a meta-analysis.Psychological bulletin · 2013Pooled it
- Effects of Escitalopram Administration on Face Processing in Intermittent Explosive Disorder: An fMRI Study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Regional brain glucose uptake distinguishes suicide attempters from non-attempters in major depression.Archives of suicide research : official journal of the International Academy for Suicide Research · 2013Trial
- Plasma and cerebrospinal fluid inflammatory markers and human aggression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Salivary cortisol awakening levels are reduced in human subjects with intermittent explosive disorder compared with controls.Psychoneuroendocrinology · 2023Article
- Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder.Frontiers in psychiatry · 2022Article
- Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin.Neuroscience bulletin · 2019Article
- Childhood serotonergic function and early adult outcomes in youth with ADHD: A 15-year follow-up study.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2018Article
- Executive (dys)function after traumatic brain injury: special considerations for behavioral pharmacology.Behavioural pharmacology · 2018Review
- Monoaminergic levels at the forebrain and diencephalon signal for the occurrence of mutualistic and conspecific engagement in client reef fish.Scientific reports · 2018Article
- Article
- Is Toxoplasma gondii a Trigger of Bipolar Disorder?Pathogens (Basel, Switzerland) · 2017Review
- The Neurobiology of Mutualistic Behavior: The Cleanerfish Swims into the Spotlight.Frontiers in behavioral neuroscience · 2017Review
- Social cognition in Intermittent Explosive Disorder and aggression.Journal of psychiatric research · 2016Article
- White Matter Integrity Reductions in Intermittent Explosive Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- A Population-Based Study of the Prevalence and Correlates of Self-Harm in Juvenile Detention.PloS one · 2016Article
- Morphometric analysis of amygdla and hippocampus shape in impulsively aggressive and healthy control subjects.Journal of psychiatric research · 2015Article
- Cerebrospinal fluid inflammatory cytokines and aggression in personality disordered subjects.The international journal of neuropsychopharmacology · 2015Article
- Cerebrospinal fluid and plasma C-reactive protein and aggression in personality-disordered subjects: a pilot study.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Central serotonergic (5-HT) activity has long been implicated in the regulation of impulsive aggressive behavior. This study was performed to use a highly selective agent for 5-HT (d-Fenfluramine, d-FEN) in a large group of human subjects to further explore this relationship dimensionally and categorically. One hundred and fifty healthy subjects (100 with personality disorder, PD and 50 healthy volunteer controls, HV) underwent d-FEN challenge studies. Residual peak delta prolactin (DeltaPRL[d-FEN]-R; ie, after the removal of potentially confounding variables) was used as the primary 5-HT response variable. Composite measures of aggression and impulsivity were used as dimensional measures, and history of suicidal/self-injurious behavior as well as the presence of intermittent explosive disorder (IED) were used as categorical variables. DeltaPRL[d-FEN]-R responses correlated inversely with composite aggression, but not composite impulsivity, in all subjects and in males and females examined separately. The correlation with composite aggression was strongest in male PD subjects. DeltaPRL[d-FEN]-R values were reduced in PD subjects with a history of suicidal behavior but not, self-injurious behavior. DeltaPRL[d-FEN]-R values were also reduced in patients meeting Research Criteria for IED. Physiologic responses to 5-HT stimulation are reduced as a function of aggression (but not generalized impulsivity) in human subjects. The same is true for personality disordered subjects with a history of suicidal, but not self-injurious, behavior and for subjects with a diagnosis of IED by research criteria. These data have particular relevance to the notion of impulsive aggression and the biological validity of IED.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.